Main description:

This book on NeuroAIDS, a collection of chapters written by experts and specialists from around the world, provides a global perspective on HIV and NeuroAIDS in the field, clinic, and laboratory. The chapters address the comorbidity of HIV and other infectious agents, including Zika virus, Ebola, Chagas disease, TB and HCV. Also discussed are key topics, such as:

* Molecular socioepidemiology

* Global HIV and NeuroAIDS

* Neuropathology

* cART and blood-brain barrier penetration

* HIV replicative oscillations

* HIV and SIV evolution

* Psychiatric comorbidities

* Neurosyphilis

* The examination of current and innovative models of translational research to translational effectiveness

Contents:

ForwardPreface
Chapter 1Multidisciplinary Approach to HIV/AIDS: Historical PerspectiveClyde B. McCoy*, A. Jeanene Bengoa*, Duane C. McBride, Brian T. Foley, Shikha Puri, Alejandro J. Mendez, and Paul Shapshak
Chapter 2Global Issues in NeuroAIDSJennifer Massey* and Bruce Brew
Chapter 3HIV-1 related Central Nervous System Diseases: Pathogenesis, Diagnosis, and Treatment - An Indian ScenarioSudharsana Sundarrajan, Sajitha Lulu, and Mohanapriya Arumugam*
Chapter 4HIV-1 Diversity in BrazilRodrigo Pessoa and Sabri Saeed Sanabani*
Chapter 5HIV and SIV EvolutionBrian T. Foley*
Chapter 6Human Brain Imaging in HIV and NeuroAIDSMona A. Mohamed* and Peter Barker
Chapter 7HIV Neuroinvasion Suzanne Gartner* and Yiling Liu
Chapter 8Neuropathology of HIV-1 DiseaseVirawudh Soontornniyomkij*
Chapter 9HIV-related Peripheral Nervous System IllnessJocelyn Jiao, David M. Simpson, and Jessica Robinson-Papp*
Chapter 10The Role of Early Life Programming in Vulnerability and Resilience in Relation to HIVLuba Sominsky* and Deborah Hodgson
Chapter 11Neurocognition in Viral Suppressed HIV-Infected ChildrenClaudia S. Crowell* and Kathleen Malee
Chapter 12Psychiatric Comorbidities in HIV-InfectionApril D. Thames* and Jacob D. Jones
Chapter 13Toward an Iterative Approach to Preventing HIV Risk Among Young MSMJ. Bryan Page
Chapter 14NeuroAIDS in Drug Abusers - Associations with Oral ManifestationsFariba S. Younai*
Chapter 15Socioepidemiology of Injection Drug Users in Miami and HIV-1B Envelope (V1-V5) Genetic Diversity: A Preliminary StudyPaul Shapshak*, Brian T. Foley, Seetharaman Balaji, David M. Segal, Clyde McCoy, and J. Bryan Page
Chapter 16The persistence of HIV associated neurocognitive disorder (HAND) in the era of combined antiretroviral therapy (cART)Elyse J. Singer* and Natasha M. Nemanim
Chapter 17Antiretroviral Therapy - Brain PenetrationCharurut Somboonwit*, Jose A Montero, John T. Sinnott, and Paul Shapshak
Chapter 18Molecular Mechanisms of Cognitive Impairment in Patients with HIV Infection: Application of Bioinformatics and Data-MiningLuca Giacomelli*, Francesco Chiappelli, Bruno Orlando, Victor Sivozhelezov, and Roberto Eggenhoeffner

Chapter 19Genetic, Epigenetic, and Transcriptomic Studies of NeuroAIDS Andrew J. Levine*, Kumud K. Singh, Asha R. Kallianpur
Chapter 20NeuroAIDS: A Review of Gene Expression in Neurons, Astrocytes and OligodendrocytesJeanie McGee and Alireza Minagar*
Chapter 21Neuronal Apoptotic Pathways in HIV Associated Dementia, Alzheimer's Disease, Parkinson's Disease, and Huntington's DiseaseFatten F. Elkomy, Andrew J. Levine, Elyse Singer, Charurut Somboonwit, Todd Wills, Kaley Tash, John T. Sinnott, Sally Alrabaa, Anteneh Addisu, Hector Rodriguez, Francesco Chiappelli, Toni Kazic, and Paul Shapshak*
Chapter 22Clinical Relevance of Humanized MiceRachel Samantha Resop, Irene Jane Kim, Huy Nguyen, and Dimitrios Nikolaos Vatakis*
Chapter 23HIV and StrokeSouvik Sen*, Lauren Giamberardino, and Parth Thakker
Chapter 24Hepatitis C and HIV Neurological ImplicationsShuchi Pandya, Misbahuddin Syed, Manuel Castro, Jamie P. Morano, and Beata Casanas*
Chapter 25Central Nervous System Reactivation of Chagas Disease in Immuno-compromised Patients with HIV/AIDSSilvana Maria Eloi-Santos*, Unai Tupinambas, Helena Duani, and Jose Eymard Homem Pittella
Chapter 26Central Nervous System TuberculosisBeata Casanas*, Douglas Holt, and Kelly Kynaston
Chapter 27Neurosyphilis and HIV infectionAnteneh Addisu, Beata C Casanas, and Sally Alrabaa
Chapter 28Orthopoxviruses and Human DiseaseRobert Castro and Beata Casanas*
Chapter 29Opportunistic Neurologic Infections in Patients Infected with Human Immunodeficiency VirusKelly Kynaston, Minh Ho, Robert Castro, and Jose Montero*
Chapter 30Zika Virus and HIV/AIDSA. Jeanene Bengoa*, Clyde B. McCoy*, Brian T. Foley, Shikha Puri, Alejandro J. Mendez, and Paul Shapshak
Chapter 31Global Convergent Translational Science for Neuro-Involvement in Ebola Viral Disease: Lessons Learned from Neuro-AIDSFrancesco Chiappelli*, Allen M. Khakshooy, Andre Barkhordarian, Vandan R. Kasar, Melissa Nahcivan, Mia T. Nguyen, Jeong Min (Grace) Hwang, Marena Martinez Kutschman, Angela Du, and Nashwa Softo
Chapter 32Sequence Accuracy in Primary Databases: A case study on HIV-1BSeetharaman Balaji*, Ramachandran Akash, Nandy Krittika, and Paul Shapshak
Chapter 33Amyloidogenic Pattern Prediction of HIV-1 ProteinsPatil Sneha, Seetharaman Balaji*, and Paul Shapshak
Chapter 34On the Potential for Multiscale Oscillatory Behavior in HIVAlexander V. Ratushny*, Patrick De Leenheer, Sergei I. Bazhan, Gennady A. Bocharov, Tamara M. Khlebodarova, and Vitaly A. Likhoshvai
Chapter 35Short oligo-peptide T-cell epitopes in HIV-1/AIDS vaccine development: Current status, design, promises and challengesPandjassarame Kangueane*, Kumar Viswapoorani, Christina Nillofer, Subramani Manimegalai, Murugan Sivagamy, Uma Kangueane, Gopichandran Sowmya, and Meena Kishore Sakharkar
Chapter 36HIV-1 Envelope (ENV) GP160 trimer protein complex SPIKE as a recombinant macro-molecular assembly vaccine component candidate - Current opinionChristina Nilofer, Arumugam Mohanapriya, and Pandjassarame Kangueane*
Chapter 37Gene Therapy Blueprints for NeuroAIDSHector E. Rodriguez, Seetha Lakshmi, Charurut Somboonwit, Asa Oxner, Lucy Guerra, Anteneh Addisu, Louise Gutierrez, John T. Sinnott, Christina Nilofer, Pandjassarame Kangueane, and Paul Shapshak*

Chapter 38Biostatistical Concerns in HIV ResearchRobert C. Duncan*