Main description:

Engineering 3D Tissue Test Systems provides an introduction to, and unique coverage of, a rapidly evolving area in biomaterials engineering. It reveals the current and future research responses, the current and future diagnostic applications, and provides a comprehensive overview to foster innovation. It offers insight into the importance of 3D systems and their use as benchtop models, spanning applications from basic scientific research to clinical diagnostics. Methods and limitations of building 3D tissue structures are evaluated, with attention given to the cellular, polymeric, and fabrication instrumentation components. The book covers the important aspects of polymeric tissue test systems, highlighting the needs and constraints of the industry, and includes a chapter on regulatory and pricing issues.

Contents:

Chapter 1 Introduction to 3D Test Systems

Karen J. L. Burg, Didier Dreau, and Timothy Burg

Section I Biofabrication Considerations

Chapter 2 Biofabrication

Jordon Gilmore and Timothy Burg

Chapter 3 Bioreactor Instrumentation and Control for 3D Cellular and

Tissue Systems

Steve Warren

Chapter 4 Control of 3D Environment: Redesign of the Flow Loop

Bioreactor to Control Mitral Valve Regurgitation

Patrick S. Connell, Dragoslava P. Vekilov,

and K. Jane Grande-Allen

Chapter 5 Nipple and Breast Construction: In Vitro and In Vivo Assessment

Maria Yanez, Scott Collins, and Thomas Boland

Chapter 6 3D Cancer Spheroid Biofabrication Using Thermal Inkjet-Based

Bioprinting for Rapid Screening

Jorge I. Rodriguez-Devora, Christopher Moody, Aesha Desai,

Karen J. L. Burg, and Delphine Dean

Section II Materials Considerations

Chapter 7 Control Testing and Effect of Manufacturing Parameters on

the Biocompatibility of Polypropylene Mesh Implants

Ahmed El-Ghannam

Chapter 8 Scaffolds for 3D Model Systems in Bone Regenerative

Engineering

Keshia Ashe, Seth Malinowski, Yusuf Khan, and Cato T. Laurencin

Chapter 9 Engineered Composites for 3D Mammary Tissue Systems

Cheryl T. Gomillion, Chih-Chao Yang, Didier Dreau, and

Karen J. L. Burg

Chapter 10 Mineralized 3D Culture Systems for Studying Bone Metastatic

Breast Cancer

Frank He, Siyoung Choi, Lara A. Estroff, and Claudia Fischbach

Chapter 11 Design Considerations for 3D Cardiovascular Tissue Scaffolds

Scott Cooper, Christopher Moraes, and Richard L. Leask

Section III Biological Considerations

Chapter 12 Pro- and Anti-Inflammatory Cytokine Signaling within 3D

Tissue Models

Stephen L. Rego, Tian McCann, and Didier Dreau

Chapter 13 Cell-Cell Communications through Gap Junctions and Cancer

in 3D Systems

Stephanie Nicole Shishido and Thu Annelise Nguyen

Chapter 14 Advances in Breast Stem Cell Knowledge through 3D Systems

Kerri W. Kwist and Brian W. Booth

Chapter 15 Shape Matters: Understanding the Breast through 3D

Tissue Culture Models

Lucia Speroni, Ana M. Soto, and Carlos Sonnenschein

Chapter 16 Cells and Tissue Structures in Cardiovascular 3D Tissue Systems

Justin McMahan, Rachel Hybart, and C. LaShan Simpson

Chapter 17 Signaling and Architectural Cues Necessary for 3D Diabetic

Tissue Models

Rosalyn D. Abbott and David L. Kaplan

Chapter 18 Optimizing 3D Models of Engineered Skeletal Muscle

Megan E. Kondash, Brittany N. J. Davis, and George A. Truskey

Chapter 19 Recapitulating the Microenvironment of Glioblastoma

Multiforme Using 3D Tissue Culture Models

Meghan Logun, Steven Stice, and Lohitash Karumbaiah

Section IV Business Considerations

Editor's Note on Business Considerations

Chapter 20 Bringing Regenerative Medicine to Patients: The Coverage,

Coding, and Reimbursement Processes

Khin-Kyemon Aung, Scott Levy, and Sujata K. Bhatia