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Voltage-Gated Ion Channels as Drug Targets, Volume 29
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Main description:

Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. It is for medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.


Contents:

Preface.1. Introduction-On Ion Channels (M. Gopalakrishnan, et al.).2. The Voltage-gated Ion Channel Superfamily (W. Catterall).3. State-dependent Drug Interactions with Ion Channels (S. McDonough & B. Bean).4. Assay Technologies: Techniques Available for Quantifying Drug-Channel Interactions (D. Leishman & G. Waldron).5. Calcium Channels (C. Doering & G. Zmponi).6. Sodium Channels (D. Krafte, et al.).7. Potassium Channels (M. Gopalakrishnan, et al.).8. Genetic and Acquired Channelopathies (K. Bracey & D. Wray).Index.


PRODUCT DETAILS

ISBN-13: 9783527607747
Publisher: John Wiley & Sons Ltd (Wiley-VCH Verlag GmbH)
Publication date: October, 2006
Pages: 492
Dimensions: 186.00 x 246.00 x 186.00

Subcategories: Pharmacology