The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices. The stand-alone chapters cover various topics - from metabolite identification to fast chromatography with UPLC - and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART.
With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.
Strategies and Techniques for Bioanalytical Assays as Part of New Drug Discovery, Walter A. Korfmacher The Drug Discovery Process: From Molecules to Drugs, Mike S. Lee and Steven E. Klohr PK Principles and PK/PD Applications, Hong Mei and Richard A. Morrison Mass Spectrometry for In Vitro ADME Screening, Inhou Chu Metabolite Identification Strategies and Procedures, Ragu Ramanathan, S. Nilgun ComezogE lu, and W. Griffith Humphreys Reactive Metabolite Screening and Covalent-Binding Assays, Gerard Hopfgartner Fast Metabolite Screening in a Discovery Setting, Xiaoying Xu Fast Chromatography with UPLC and Other Techniques, Sam Wainhaus Supercritical Fluid Chromatography-Mass Spectrometry, Yunsheng Hsieh Biomarkers of Efficacy and Toxicity: Discovery and Assay, Joanna R. Pols Imaging Mass Spectrometry for Small Molecules, Fangbiao Li MALDI IMS for Proteins and Biomarkers, Michelle L. Reyzer and Richard M. Caprioli Ambient Ionization Methods and Their Early Applications in ADME Studies, Jing-Tao Wu Pharmaceutical Applications of Accelerator Mass Spectrometry, Lan Gao and Swapan Chowdhury