Due to major advances in understanding the biology and pathogenesis of the disease, the management of multiple myeloma is changing rapidly. New diagnostic and prognostic criteria have been introduced, and treatment options are multiplying with high-dose chemotherapy regimens, stem cell transplants, and the development of novel agents and immune-based strategies that target tumor cells directly. This book is aimed at the practitioner who is looking to put these advances into clinical context. It will serve as an up-to-date resource for treatment of myeloma and related disorders. Chapters are written by international authorities and contain color photos, diagrams, and algorithms outlining preferred treatment strategies. Relevant scientific information is integrated throughout, but the focus here is on providing practical therapeutic guidance for oncologists and hematologists caring for myeloma patients. The book covers all myeloma subtypes and related disorders, including amyloidosis, Waldenstrom macroglobulinemia, plasmacytoma, MGUS, and POEMS syndrome.
1. Diagnosis and genetic classification of MM Rafael Fonseca and P. Leif Bergsagel; 2. Staging and risk-stratification of MM Keith Stewart; 3. Treatment of newly diagnosed MM S. Vincent Rajkumar and Robert A. Kyle; 4. Maintenance therapy in MM Sagar Lonial and Jonathan L. Kaufman; 5. Treatment of relapsed and relapsed/refractory MM Marc S. Raab, Paul G. Richardson and Kenneth C. Anderson; 6. Diagnosis and treatment of myeloma bone disease G. David Roodman; 7. Treatment of myeloma related complications Joan Bladé and Laura Rosiñol; 8. Autologous transplantation for MM J.-L. Harousseau; 9. Allogeneic stem cell transplantation for MM William I. Bensinger; 10. Immunoglobulin light chain amyloidosis (AL) Morie A. Gertz and Suzanne R. Hayman; 11. Waldenstrom's macrogloblinemia/lymphoplasmacytic lymphoma Steven P. Treon and Giampaolo Merlini; 12. Diagnosis, risk-stratification and management of solitary plasmacytoma Meletios A. Dimopoulos and Efstathios Kastritis; 13. Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma Robert A. Kyle and S. Vincent Rajkumar; 14. Diagnosis and treatment of POEMS syndrome Angela Dispenzieri.