Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. The challenge for existing stem cell-based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo, because stem cells are rather sensitive to even minute changes in their environment. Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues. This book presents the latest micro- and nanotechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. Moreover, it covers and details cutting-edge research in nano- and microfabrication techniques and biomaterials for the regeneration of various tissues and organs, such as bone, cartilage, craniofacial, osteochondral, muscle, bladder, cardiac, and vascular tissues.
Nano and Microtechnology Nano/Microfibrication Techniques for Tissue and Organ Regeneration, Benjamin Holmes, Thomas J. Webster, and Lijie Grace Zhang Three Dimensional Micropatterning of Biomaterial Scaffolds for Tissue Engineering, Joseph C. Hoffmann and Jennifer L. West Nanobiotechnology and Biomaterials for Regenerative Medicine, Nupura S. Bhise and Jordan J. Green Micro- and Nanotechnology Engineering Strategies for Tissue Interface Regeneration and Repair, Torri E.Rinker and Johnna Temenoff Spatiotemporal Genetic Control of Cellular Systems, Lauren R. Polstein and Charles A. Gersbach Biomimetic Design of Extracellular Matrix-like Substrate for Tissue Regeneration, Chao Jia, Seyed Babak Mahjour, Lawrence Chan, Da-wei Hou, and Hongjun Wang Degradable Elastomers for Tissue Regeneration, G. Rajesh Krishnan, Michael J. Hill, and Debanjan Sarkar Protein Engineering Strategies for Modular, Responsive, and Spatially Organized Biomaterials, Ian Wheeldon Tissue and Organ Regeneration Design and Fabrication of Biomimetic Microvascular Architecture, Thomas M. Cervantes and Joseph P. Vacanti Tissue Engineering of Human Bladder, Anthony Atala The Self-Assembly Process of Articular Cartilage and Self-Organization in Tissue Engineering, Pasha Hadidi, Rajalakshmanan Eswaramoorthy, Jerry C. Hu, and Kyriacos A. Athanasiou Environmental Factors in Cartilage Tissue Engineering, Yueh-Hsun Yang and Gilda A. Barabino Bone Regenerative Engineering: The Influence of Micro and Nano Dimension, Roshan James, Meng Deng, Sangamesh G. Kumbar, and Cato T. Laurencin Stem Cell and Bone Regeneration, Martin L. Decaris, Kaitlin C. Murphy, and J. Kent Leach Notch Signaling Biomaterials and Craniofacial Regeneration, Thanaphum Osathanon, Prasit Pavasant, and Cecilia Giachelli Stem Cell-Based Dental, Oral and Craniofacial Tissue Engineering, Sahng G. Kim, Chang Hun Lee, Jian Zhou, Mo Chen, Ying Zheng, Mildred C. Embree, Kimi Kong, Karen Song, Susan Y. Fu, Shoko Cho, Nan Jiang, and Jeremy J. Mao Engineering Functional Bone Grafts for Craniofacial Regeneration, Pinar Yilgor Huri and Warren L. Grayson Nanotechnology in Osteochondral Regeneration, Nathan J. Castro, Joseph R. O'Brien, and Lijie Grace Zhang Aortic Heart Valve Tissue Regeneration, Bin Duan, Laura A. Hockaday, Kevin H. Kang, and Jonathan T. Butcher Micro and Nanotechnology in Vascular Regeneration, Vivian Lee and Guohao Dai Micro- and Nanofabrication Approaches to Cardiac Tissue Engineering, Nicole Trosper, Petra Kerscher, Jesse Macadangdang, Daniel Carson, Elizabeth Lipke, and Deok-Ho Kim Engineering of Skeletal Muscle Regeneration: Principles, Current State and Challenges, Weining Bian, Mark Juhas, and Nenad Bursac