Brought to you by the world s leading transplant clinicians, Textbook of Organ Transplantation provides a complete and comprehensive overview of modern transplantation in all its complexity, from basic science to gold-standard surgical techniques to post-operative care, and from likely outcomes to considerations for transplant program administration, bioethics and health policy. Beautifully produced in full color throughout, and with over 600 high-quality illustrations, it successfully: * Provides a solid overview of what transplant clinicians/surgeons do, and with topics presented in an order that a clinician will encounter them. * Presents a holistic look at transplantation, foregrounding the interrelationships between transplant team members and non-surgical clinicians in the subspecialties relevant to pre- and post-operative patient care, such as gastroenterology, nephrology, and cardiology. * Offers a focused look at pediatric transplantation, and identifies the ways in which it significantly differs from transplantation in adults.
* Includes coverage of essential non-clinical topics such as transplant program management and administration; research design and data collection; transplant policy and bioethical issues. Textbook of Organ Transplantation is the market-leading and definitive transplantation reference work, and essential reading for all transplant surgeons, transplant clinicians, program administrators, basic and clinical investigators and any other members of the transplantation team responsible for the clinical management or scientific study of transplant patients.
List of Contributors Section 1 History/Introduction 0 Introduction Allan D. Kirk and Steven B. Webber 1 A Brief History of Clinical Organ Transplantation Sir Roy Yorke Calne Section 2 Transplantation Biology Immunolgy 2 Physiology of the Immune System Heth R. Turnquist, Giorgio Raimondi, Diana Metes and Angus W. Thomson 3 Development of HLA, cross-matching, etc. Paul Terasaki 4 Transplant Antigen Biology Raja Rajalingam, Qiuheng Zhang, J. Michael Cecka and Elaine F. Reed 5 Cellular Mechanisms of Adaptive Immunology Maria-Luisa Alegre 6 Humoral Mechanisms of Adaptive Immunology William M. Baldwin III and Robert L. Fairchild 7 Innate Immunity Melissa Y. Yeung, Sacha A. De Serres and Xian C. Li 8 Mechanisms of Regulation Kathryn J. Wood, Andrew Bushell and Joanna Hester 9 The Spectrum of Alloimmunity, Heterologous Immunity, and Relevant Autoimmunity Mandy L. Ford, Andrew B. Adams and Christian P. Larsen 10 Fundamental Concepts Regarding Graft Injury and Regeneration: Tissue Injury, Tissue Quality, and Recipient Factors Chatchai Kreepala, Konrad S. Famulski and Philip F. Halloran 11 Mechanisms of Allograft Tolerance Allan D. Kirk and Raul Badell 12 Xenoimmunity Peter J. Cowan and Anthony J.F. d Apice Experimental Transplantation 13 In Vitro Models of Alloreactivity Robert L. Fairchild, Charles A. Su, Anna Valujskikh and William M. Baldwin III 14 Small Animal Models Lakshman Gunaratnam, Anthony M. Jevnikar and Roslyn B. Mannon 15 Large Animal Models Douglas J. Anderson, Benjamin M. Martin, Allan D. Kirk and David H. Sachs 16 Advancing In Silico: Studying Global Gene Expression Using Functional Genomics for Transplantation Research Steven Head, Sunil M. Kurian and Daniel R. Salomon Mechanisms of Immune Modulation 17 Pathways for Immune Manipulation Jason R. Lees, Agnes M. Azimzadeh, Yaozhong Ding, Jiangnan Xu and Jonathan S. Bromberg 18 Future Pathways for Immune Manipulation Allison Webber and Flavio Vincenti Section 3 Organ Procurement Procurement & Allocation 19 Organ Procurement & Allocation Jennifer Porter, Lori E. Brigham and Susan Gunderson 20 Deceased donor management John Fung, Koji Hashimoto, Bijan Eghtesad, Daniel J. Lebovitz and Melissa Watson Techniques for Organ Procurement 21 Donation after Brain Death Rupert Oberhuber, Timm Heinbokel, Zain Khalpey, Sayeed Malek and Stefan G. Tullius 22 Donation after Cardiac Death Chandrasekar Santhanakrishnan and Anthony M. D Alessandro 23 Living Donor: Kidney Ken Newell 24 Living Donor: Liver Koji Hashimoto, Cristiano Quintini and Charles M. Miller Preservation and Resuscitation 25 Organ Preservation and Resuscitation: Abdominal Organs Henri G.D. Leuvenink and Rutger J. Ploeg 26 Organ Preservation and Resuscitation: Thoracic Organs Jonathan C. Yeung, Marcelo Cypel, John M. Craig and Shaf Keshavjee 27 Kidney Paired Donation Networks Adam W. Bingaman and Cathi L. Murphey Section 4 Pre-operative Management Patient Selection and Indications for Organ Transplantation 28 Patient Selection and Indications for Organ Transplantation: Kidney Jeremy Goodman and Robert S. Gaston 29 Patient Selection and Indications for Organ Transplantation: Liver Kimberly A. Brown and Marwan Kazimi 30 Patient Selection and Indications for Organ Transplantation: Heart Andrew L. Smith and Daniel B. Sims 31 Patient Selection and Indications for Organ Transplantation: Lung Edward R. Garrity, Jr. and Julia B. Becker 32 Patient Selection and Indications for Organ Transplantation: Pancreas & Islet Alexandra Turner and Nicole A. Turgeon 33 Patient Selection and Indications for Organ Transplantation: Intestinal & Multivisceral Douglas G. Farmer and Robert S. Venick 34 Role of Primary Care Provider in Care of Abdominal Organ Transplant Patients Peggy B. Hasley, Kristine S. Schonder and Ron Shapiro 35 Role of Primary Care Provider in Care of Thoracic Organ Transplant Patients Remzi Bag, Arvind Bhimaraj and Sireesha Garikipati The Histocompatibility Lab 36 Alloantibodies, Sensitization and Virtual Crossmatching Robert Bray and Howard Gebel Waiting List Management 37 Waiting List Management: Kidney Phuong-Thu T. Pham, Phunong-Chi T. Pham and Gabriel M. Danovitch 38 Waiting List Management: Liver John G. O Grady 39 Waiting List Management: Heart Howard J. Eisen 40 Waiting List Management: Lung E. Clinton Lawrence and David Neujahr 41 Waiting List Management: Pancreas and Islet Jon S. Odorico 42 Waiting List Management: Intestinal and Multi-visceral Kareem M. Abu-Elmagd and Guilherme Costa Intensive Care in End Organ Failure 43 Intensive Care in End Organ Failure: Liver Ram Subramanian and Jenny Han 44 Intensive Care in End Organ Failure: Heart Maryl R. Johnson, Josef Stehlik, Deborah Budge and Michael S. Kiernan 45 Intensive Care in End Organ Failure: Lung John Adam Reich and R. Eliot Fagley 46 Dialysis Myriam Farah and John S. Gill 47 Artificial Liver, In Vivo Tissue Engineering, and Organ Printing Solutions for Organ Scarcity Peter Neuhaus, Igor M. Sauer and Nathanael Raschzok 48 Ventricular Assist Devices O.H. Frazier and Steven M. Parnis 49 Artificial Heart Hannah Copeland, Jennifer Berumen, Richard G. Smith and Jack G. Copeland 50 The Development and Use of Artificial Lungs in Lung Transplantation A. Claire Watkins and Bartley P. Griffith 51 Totally Artificial Pancreas Desmond Barry Keenan and Garry M. Steil 52 Tissue & Organ Bioengineering Tracy C. Grikscheit and Erik R. Barthel Organ Acceptance and Risk Management Assessment 53 Standard and Extended Criteria Donors Stephen T. Bartlett and Matthew Cooper 54 Donation after Cardiac Death Silke Niederhaus and Anthony M. D Alessandro Section 5 Transplant Procedure & Surgical Technique 55 Kidney Transplantation Procedure & Surgical Technique Paul L. Tso and Thomas C. Pearson 56 Liver Transplantation Procedure & Surgical Technique Joseph F. Magliocca, Steven I. Hanish, Eugenia K. Page and Stuart J. Knechtle 57 Living Donor Liver Transplantation Procedure & Surgical Technique Sung-Gyu Lee, Deok-Bog Moon and Chung-Man Namgoong 58 Heart Transplantation Procedure & Surgical Technique John M. Craig, Soyoung Lee, Gus J. Vlahakes and Joren C. Madsen 59 Lung Transplantation Procedure & Surgical Technique R. Duane Davis 60 Pancreas Transplantation Procedure & Surgical Technique Jon S. Odorico, Hans Sollinger and Dixon Kaufman 61 Islet Cell Transplantation Procedure & Surgical Technique A.M. James Shapiro and Camillo Ricordi 62 Intestinal Transplantation Procedure & Surgical Technique Thomas Fishbein 63 Multi-visceral Transplantation Alan Langnas and Lokesh Bathla 64 Vascularized Composite Allograft (VCA) Transplantation Procedure & Surgical Technique Gerald Brandacher, Jaimie T. Shores, Chad R. Gordon, Damon S. Cooney and W.P. Andrew Lee Section 6 Post-transplant Management Immunosuppressive Therapy 65 Induction Therapy Ali H. Charafeddine and Allan D. Kirk 66 Maintenance Therapy Karen L. Hardinger, Daniel C. Brennan and Christina L.M. Klein 67 Rescue Therapy: Approaches to the Treatment of Acute and Chronic Allograft Injury Mark D. Stegall and Patrick G. Dean 68 Desensitization Protocols Carmen Lefaucheur and Denis Glotz Clinical Allograft Rejection Syndromes: Diagnosis & Management 69 Clinical Allograft Rejection Syndromes: Kidney Brian J. Nankivell 70 Clinical Allograft Rejection Syndromes: Liver Sandy Feng and Matthew H. Levine 71 Clinical Allograft Rejection Syndromes: Heart Keyur B. Shah, Joren C. Madsen and Mandeep R. Mehra 72 Clinical Allograft Rejection Syndromes: Lung David C. Neujahr 73 Clinical Allograft Rejection Syndromes: Pancreas and Islet Parsia A. Vagefi and Peter G. Stock 74 Clinical Allograft Rejection Syndromes: Intestinal Gennaro Selvaggi, Andreas Tzakis, Akin Tekin, Jennifer Garcia, Ji Fan and Philip Ruiz, Jr. 75 Clinical Allograft Rejection Syndromes: VCA Stefan Schneeberger and Gerald Brandacher 76 Clinical Transplantation Tolerance Tatsuo Kawai, David H. Sachs and A. Benedict Cosimi Clinical Recurrent Disease: Diagnosis and Management 77 Post-transplant Recurrent Disease: Kidney and Pancreas Philip J. O Connell and Lorna K. Henderson 78 Post-transplant Recurrent Disease: Liver Samir Parekh and James R. Spivey 79 Post-transplant Recurrent Disease: Heart Jignesh K. Patel and Jon A. Kobashigawa 80 Post-transplant Recurrent Disease: Lung Todd L. Astor Histopathological Syndromes of Graft Rejection and Recurrent Disease 81 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Kidney Alton B. Farris and Michael H. Mengel 82 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Liver Anthony J. Demetris, Marta I. Minervini, Michael A. Nalesnik, Erin Rubin, Parmjeet Randhawa and Eizaburo Sasatomi 83 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Heart E. Rene Rodriguez and Carmela D. Tan 84 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Lung Carol Farver and W. Dean Wallace 85 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Pancreas and Islet Cinthia B. Drachenberg and John C. Papadimitriou 86 Histopathological Syndromes of Graft Rejection and Recurrent Disease: Intestinal Phillip Ruiz Jr., Jennifer Garcia, Akin Tekin, Seigo Nishida and Andreas Tzakis 87 Histopathological Syndromes of Graft Rejection and Recurrent Disease: VCA Alexandra P. Turner, Alton B. Farris, III, Alessandrina M. Freitas and Linda C. Cendales Post-operative Monitoring 88 Cardiovascular Disease and Preventive Healthcare Steve Pastan and Divya Gupta 89 Post-Transplant Monitoring for HLA Antibody Robert A. Bray and Howard M. Gebel 90 Biomarkers and Alloimmune Monitoring Oriol Bestard, Birgit Sawitzki and Alberto Sanchez-Fueyo 91 Protective Immune Competence Aneesh Mehta Transplant Infectious Diseases 92 Donor-derived Infections Marissa B. Wilck and Emily A. Blumberg 93 Peri-operative Infectious Disease Daniel Kaul and Michael Green 94 Post-Transplant Infections Jay A. Fishman and Robin K. Avery Malignancy in Transplantation 95 General Malignancy Oriol Bestard, Josep M. Cruzado and Josep M. Grinyo 96 Post-Transplant Lymphoproliferative Disorders Steven B. Webber and Michael Green Pregnancy and Contraception in Transplantation 97 Pregnancy and Contraception in Transplantation Serban Constantinescu, Veronica Gomez-Lobo, John M. Davison, Michael J. Moritz, and Vincent T. Armenti The Transplant Pharmacopeia 98 Drugs Specifically Approved for Transplant Indications Winston A. Ally and Avinash Agarwal 99 Infectious Disease Prophylaxis G. Marshall Lyon III 100 Metabolic and Endocrine Management Naim Issa, Scott A. Reule and Aleksandra Kukla 101 Off-Label Use of Immunosuppressive Agents in Solid Organ Transplantation Jill C. Krisl, Rita R. Alloway, and E. Steve Woodle 102 Drug Interactions William D. Simmons, Pamala A. Jacobson and Karen L. Hardinger Section 7 Long-term Transplant Outcomes 103 Long-term Outcomes of Renal Transplant Recipients Sundus A. Lodhi and Neema Stephens 104 Factors Influencing Long-Term Survival after Liver Transplantation Heidi Yeh, Paulo Martins and James F. Markmann 105 Long-term Transplant Outcomes: Heart Transplantation Michelle M. Kittleson and Jon A. Kobashigawa 106 Long-term Transplant Outcomes: Lung and Heart-Lung Transplantation Toshihiro Okamoto, David Wheeler, and Kenneth R. McCurry 107 Long-term Transplant Outcomes: Pancreas Transplantation Philip Y. Wai and Hans W. Sollinger 108 Long-term Transplant Outcomes: Islet Transplantation A.M. James Shapiro and Camillo Ricordi 109 Long-term Transplant Outcomes: Intestinal and Multi-visceral Transplantation Jennifer Garcia, Gennaro Selvaggi, Akin Tekin, Philip Ruiz Jr. and Andreas Tzakis 110 Long-term Transplant Outcomes: Vascularized Composite Allograft (VCA) Transplantation Alessandrina M. Freitas and Linda C. Cendales Section 8 Pediatric Transplant 111 An Introduction to Pediatric Organ Transplantation Allan D. Kirk and Steven B. Webber 112 Develomental Immunology: From Birth to Adult Simon Urschel and Lori J. West 113 Pediatric Transplant: Kidney Bill Harmon 114 Pediatric Transplant: Liver John C. Bucuvalas and Sandy Feng 115 Pediatric Transplant: Heart Steven B. Webber 116 Pediatric Transplant: Lung Stuart C. Sweet and Albert Faro 117 Pediatric Transplant: Intestinal and Multivisceral Transplant Douglas G. Farmer Special Pediatric Considerations 118 Growth and Development After Organ Transplantation Franz Schaefer 119 Cognitive Development and Functional Outcomes Estella M. Alonso, Saeed Mohammad and Lisa G. Sorensen 120 Nonadherence, Psychosocial Adaptation and Its Effects in Pediatric Transplantation Robert Ettenger and Margaret L. Stuber 121 Management of the Recipient in the Transition from Pediatric to Adult Care Sandi Amaral and Lorraine E. Bell Section 9 Transplant Administration 122 Transplant Coordination Dianne LaPointe Rudow 123 The Transplant Pharmacy Christin C. Rogers, Nicole A. Pilch, Eric M. Tichy, Lonnie D. Smith, David J. Taber and Rita R. Alloway 124 Inpatient Transplant Unit Management Linda Ohler, Margaret J. Schaeffer, Kelly Carter and Donna B. George 125 Transplant Clinic Management Elizabeth A. Kallenborn, Chris Shay-Downer, Kathy Schwab and Shelley Zomak 126 Transplant Center Management and Leadership A Case for Structured Intrapreneurship Luke Preczewski, Gwen McNatt and Michael Abecassis 127 Transplant Quality Programs Christian Morath, Peter Schemmer and Martin G. Zeier 128 National and International Transplant Management and Oversight Jeremy Chapman, Virginia A. McBride, Esther-Marie Carmichael and Linda Ohler Transplant Education 129 Abdominal Solid Organ Transplantation Fellowship Training Rachel C. Forbes and Mitchell L. Henry 130 Medical Solid Organ Transplant Fellowship Deirdre Sawinski and Roy D. Bloom 131 Transplantation in General Medical Education Douglas J. Norman and Rowena de los Santos Section 10 Clinical Trials & Data Management 132 Building and Sustaining a Local Data Management Program Regina Eady, Tim Morris, Marc J. Overcash and Jeff Weaver 133 National Transplant Data Registries and Population Studies Allan Massie and Dorry L. Segev 134 Clinical Research Methods and Analysis in Organ Transplantation Jesse D. Schold and S. Joseph Kim 135 Comparative Effectiveness in Transplant Edward A. Meister and Bruce Kaplan Section 11 Transplant Policy Transplant Ethics 136 Transplant Ethics for Clinicians Richard N. Formica Jr. and Francis L. Delmonico 137 Organ Allocation Richard S. Luskin and Alexandra K. Glazier 138 Living Donation Alice Peng and Andrew Klein 139 Cultural Variations Chris J. Callaghan and J. Andrew Bradley Economic and Societal Impact of Transplantation and Transplant Policy 140 Federal and Private Insurance Coverage for Transplant Policy Timothy L. Pruett 141 Drug Development in Solid Organ Transplantation and the Approval Process for Transplant Immunosuppressants Candace Wang, J. Mark Hexham, Alan Slade, Peter Heining, Ronald Van Valen, Guido Junge and Marc I. Lorber Index