Now in its fourth edition Testosterone: Action, Deficiency, Substitution provides the most up-to-date and comprehensive source of information on testosterone and its role in human physiology and pathology. It covers biosynthesis and mechanisms of action and reviews their effects on brain and behavior, spermatogenesis, hair growth, bones, muscles, erythropoiesis, the cardiovascular system and the prostate. The therapeutic uses of testosterone preparations are carefully evaluated as well as its abuse and detection in competitive sport. This new edition also devotes sections to exploring the effects of testosterone on female physiology and sexual function, and the experimental use of testosterone in male hormonal contraception. Testosterone: Action, Deficiency, Substitution has been written and edited by world experts in the fields of clinical andrology and endocrinology and provides a unique and invaluable guide for andrologists, endocrinologists, urologists, internists and those working in reproductive medicine.
Preface; 1. The medical and cultural history of testosterone and the testes Eberhard Nieschlag and Susan Nieschlag; 2. Testosterone: biosynthesis, transport, metabolism and (non-genomic) actions C. Marc Luetjens and Gerhard F. Weinbauer; 3. Pathophysiology of the androgen receptor Olaf Hiort, R. Werner and Michael Zitzmann; 4. Methodology for measuring testosterone, DHT and SHBG in a clinical setting Manuela Simoni, Flaminia Fanelli, Laura Roli and Uberto Pagotto; 5. The behavioral correlates of testosterone John Bancroft; 6. The role of testosterone in spermatogenesis Liza O'Donnell and Robert I. McLachlan; 7. Androgens and hair: a biological paradox with clinical consequences Valerie Anne Randall; 8. Testosterone and bone Dirk Vanderschueren, Mieke Sinnesael, E. Gielen, F. Claessens and S. Boonen; 9. Androgens effects on the skeletal muscle Shalender Bhasin, Ravi Jasuja, Carlo Serra, Rajan Singh, Thomas W. Storer, Wen Guo, Thomas G. Travison and Shezad Basaria; 10. Testosterone and cardiovascular disease Kevin S. Channer and T. Hugh Jones; 11. Testosterone, obesity, diabetes and the metabolic syndrome T. Hugh Jones and Kevin S. Channer; 12. Testosterone and erection Mario Maggi and Hermann M. Behre; 13. Testosterone and the prostate John T. Isaacs and Samuel R. Denmeade; 14. Clinical use of testosterone in hypogonadism and other conditions Eberhard Nieschlag and Hermann M. Behre; 15. Testosterone preparations for clinical use in males Hermann M. Behre and Eberhard Nieschlag; 16. Androgens in male senescence Jean-Marc Kaufman, Guy T'Sojen and Alex Verleulen; 17. Androgen therapy in non-gonadal disease David J. Handelsman; 18. Review of guidelines on diagnosis and treatment of testosterone deficiency Ronald S. Swerdloff and Christina C. L. Wang; 19. Pathophysiology of estrogen action in men Vincenzo Rochira, Daniele Santi and Cesare Carani; 20. Dehydroepiandrosterone (DHEA) and androstenedione Bruno Allolio, Wiebke Arlt and Stefanie Hahner; 21. The state-of-the-art in the development of selective androgen receptor modulators (SARMs) Ravi Jasuja, M. Zacharov and Shalender Bhasin; 22. The essential role of testosterone in hormonal male contraception Eberhard Nieschlag and Hermann M. Behre; 23. Testosterone use in women Susan R. Davis; 24. Detection of illegal use of androgens and SARMs Wilhelm Schänzer and Mario Thevis; 25. Clinical effects of doping with anabolic steroids Elena Vorona and Eberhard Nieschlag; Index.