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Stem Cells and Myocardial Regeneration
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Main description:

Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-based strategies for the prev- tion and treatment of chronic heart failure (CHF). Not that long ago we believed we were born with a set number of cardiac myocytes and that once damaged there was no hope to replace them. The interest in the field stems from the magnitude of cardiovascular disease in the world. Our ability to treat and help patients survive acute myocardial infarction (MI) has resulted in a near epidemic of CHF. There are more than 5 million Americans who currently carry the diagnosis of CHF. With more than 1 million MIs a year in the United States, there are approx 500,000 new cases of CHF diagnosed each year. The goal of Stem Cells and Myocardial Regeneration is to present, in a coherent manner, the current state of knowledge of stem cell-based therapies for cardiac dysfunction, including current findings in both the laboratory and the clinic trials. The first section of this Stem Cells and Myocardial Regeneration focuses on the magnitude of the problem and the successes and failures of what we consider optimal medical therapy. It is on this background that stem cell-based therapy needs to build.


Stem Cells and Myocardial Regeneration

Table of Contents

1. The Challenge for Stem Cell Therapy: Overview of the Problem: Heart Attack and Heart Failure
Marc S. Penn, MD, PhD
Eric J. Topol, MD
Cleveland Clinic Foundation

Cells of interest for myocardial regeneration
2. Hematopoietic Stem Cells for Myocardial Regeneration
Don Orlic, PhD
Richard O. Cannon III, M.D.
National Institutes of Health

3. Mesenchymal Stem Cells for Cardiac Therapy
Mark F. Pittenger, PhD
Osiris Therapeutics, Inc

4. Multipotent Adult Progenitor Cells
Wouter van't Hof
Niladri Mal
Amy Raber
Ming Zhang
Anthony Ting
Marc S. Penn
Robert Deans

5. Mesenchymal Progenitor Cells for Vascular Formation and Cardiac Muscle Regeneration
Silviu Itescu MD
Fiona See PhD
Timothy Martens MD
Columbia University

6. Umbilical Cord Blood Stem Cells for Myocardial Regeneration and Angiogenesis
Shyam Bhakta, MD
Mary Laughlin, MD
Case Western Reserve University

7. Endogenous Cardiac Stem Cells
Elisa Messina
Alessandro Giacomello
Eduardo Marban
University of Rome 'La Sapienza' & Johns Hopkins University

8. Embryonic Stem Cells for Myocardial Repair
Lior Gepstein, MD, PhD
Technion, Israel

Mechanisms and critical pathways involved in myocardial repair
9. Chemokine and Homing Factor Expression in Acute Myocardial Infarction and Congestive Heart Failure
Arman T. Askari, MD
Marc S. Penn, MD, PhD
Cleveland Clinic Foundation

10. Stem Cell Differentiation Towards a Cardiac Myocyte Phenotype
Andrea Ladd, PhD
Cleveland Clinic Foundation

11. Electrical Coupling and/or Ventricular Tachycardia Risk of Cell Therapy
Shuixiang Yang MD
Dayi Hu, MD, PhD
Beijing, China

12. Cell Therapy for Myocardial Damage: Arrhythmia Risk and Mechanisms
William R. Mills, MD
Kenneth R. Laurita, PhD
MetroHealth Campus, Case Western Reserve University

Strategies for Cell Delivery advantages/disadvantages
13. Aspects of Percutaneous Cellular Cardiomyoplasty
Matthew Hook, MD
Patrick Whitlow, MD
Cleveland Clinic Foundation

14. Open-Chest / Minimally Invasive Surgical Techniques
Roberto Lorusso MD, PhD
Josè L. Navia, MD
Cesare Beghi°, MD
Fernando A. Atik, MD
Cleveland Clinic Foundation, Brescia and Parma, Italy

Stem Cell Based Clinical Trials for Cardiac Dysfunction
15. Measures of Effective Cell Based Therapies
Wael A. Jaber, MD
Manuel Cerqueira, MD
Cleveland Clinic Foundation

Congestive Heart Failure
16. Whole Bone Marrow Transplantation
Emerson C. Perin, MD
Guilherme V. Silva, MD
Texas Heart Institute

17. Clinical Angioblast Therapy
Amit N. Patel, MD, MS
Jorge Genovese, MD
University of Pittsburgh Medical Center

18. Use of skeletal myoblasts for the treatment of CHF
Anthony W. Ashton
David D'Alessandro
Robert E. Michler
Albert Einstein College

Acute MI
19. Bone Marrow and Angioblast Transplantation
Marc S. Penn, MD, PhD
Samuel Unzek, MD
Niladri Mal, MD
Kai Wang, MD, PhD
Cleveland Clinic Foundation

20. Strategies for Cytokine Modification and Stem Cell Mobilization
Stephen G. Ellis, MD
Brian J. Bolwell, MD
Cleveland Clinic Foundation

Summary/Future Challenges
21 Summary and Future Challenges
Marc S. Penn, MD, PhD
Cleveland Clinic Foundation


ISBN-13: 9781597452724
Publisher: Springer (Humana Press)
Publication date: October, 2006
Pages: 400

Subcategories: Cardiovascular Medicine