The infarcted heart heals by scar formation, and large myocardial infarctions typically result in heart failure. Although cardiomyocyte cell cycle activity is present at the border zone of an infarct, and adult stem cells with the capacity to transform into various cardiac cell types and to secrete cardioprotective cytokines have been identified, the endogenous repair mechanisms in the adult heart are not sufficient for meaningful tissue regeneration.These observations, however, suggest that it may be feasible to develop interventions aimed at enhancing these processes, and, in effect, rebuild the infarcted heart. While aspects of this concept are currently being tested in pre-clinical studies as well as in clinical trials, much remains to be learned about the biological foundations of cardiac regeneration. This excellent text offers the reader a concise overview of the molecular basis of cardiac growth and regeneration, important pre-clinical studies of myocardial repair, and the early clinical experience with cell therapy. All of the authors of "Rebuilding the Infarcted Heart" have extensive experience and have published widely in the field of cardiovascular regenerative medicine
Section I: Physics and Dosimetry in Computed Tomography 1. History of Computed Tomography 2. Physics of and Approaches to Cardiovascular Computed Tomography 3. Radiation Dose in Computed Tomography 4. Cross-sectional Anatomy of the Cardiovascular System 5. Coronary Atherosclerosis and Acute Coronary Syndromes for the Cardiovascular CT Imager Section II: Clinical Cardiovascular Computed Tomography 6. Cardiovascular Computed Tomography: A Clinical Perspective IIa: Cardiac and Coronary Computed Tomography 7. Measurement of Coronary Artery Calcium by Computed Tomography 8. Coronary Calcification and Myocardial Ischemia 9. Coronary Calcium Scanning for the Prediction of Coronary Stenoses in Symptomatic Patients 10. Coronary Calcium Scanning for the Prediction of Adverse Cardiac Events in Asymptomatic Individuals 11. Progression of Coronary Calcium and its Pharmacologic Modification IIb: Computed Tomographic Coronary Angiography 12. How to do and Interpret CT Coronary Angiography 13. Computed Tomographic Coronary Angiography for the Detection of Coronary Stenoses 14. Computed Tomographic Coronary Angiography for Subclinical Coronary Artery Disease, Coronary Artery Remodelling, and Plaque Imaging 15. CT Imaging of Congenital Coronary Anomalies 16. CT Angiography of Coronary Artery Bypass Grafts 17. Assessment of Coronary Artery Stents by Coronary CT Angiography IIc: Other Applications of Cardiac and Coronary Computed Tomography 18. Computed Tomographic Imaging of the Myocardium, Cardiac Chambers and Pericardium 19. Assessment of Left Ventricular Function by Computed Tomography 20. Assessment of Heart Valve Disease by Computed Tomography 21. Cardiovascular CT in Congenital Cardiovascular Disease 22. CT Imaging of the Coronary and Pulmonary Veins: Role in teh Planning and Follow-up of Electrophysiology Procedures 23. Extracardiac Findings on Cardiac CT Imaging Peripheral Computed Tomographic Angiography 24. Computed Tomographic Angiography: Technical Considerations 25. Computed Tomographic Angiography of the Thoracic Aorta 26. Computed Tomographic Pulmonary Arteriography for the Diagnosis of Pulmonary Embolism 27. Computed Tomographic Angiography of the Abdominal Aorta and Iliac Arteries 28. Computed Tomographic Angiography of the Mesenteric Arteries 29. Computed Tomographic Angiography of the Renal Arteries 30. Computed Tomographic Angiography of the Upper Extremities 31. Computed Tomographic Angiography of the Lower Extremities 32. Computed Tomographic Angiography in Neuroradiology Section III: Emerging and Research Applications in Cardiovascular Computed Tomography 33. Cardiovascular Computed Tomography: A Research Perspective 34. Hybrid Imaging Combining Cardiovascular Computed Tomography with Single Plane Emission Computed Tomography and Positron Emission Tomography 35. Interventional Computed Tomography Combing C-arm Systems with Flat Panel Detector 36. Dual-Energy Computed Tomography 37. Imaging of Myocardial Viability and Infarction by Computed Tomography 38. Computed Tomography for the Assessment of Myocardial and Solid Organ Perfusion 39. Intravascular Contrast Agents for Cardiovascular Computed Tomography 40. Micro-computed Tomography for the Assessment of the Myocardial Microvasculature 41. Insights into Atherogenesis from Plaque Imging with Micro-computed Tomography 42. Micro-computed Tomography for the Assessment of Coronary Vasa Vasorum and Atherosclerosis.