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Pulmonary Hypertension
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Main description:

Written by internationally recognized experts, Pulmonary Hypertension bridges the gap between pulmonology and cardiology to provide clinicians in both disciplines with knowledge of the signs, symptoms, diagnosis, and pharmacologic and surgical treatments for pulmonary hypertension (PH). Through the use of clinical trials, this ground-breaking text supplies a comprehensive review of both the primary and secondary clinical and investigative aspects of this condition.

Discussing controversies and concepts in PH diagnosis and management, this guide explores:

  • classification and epidemiology, pathology, pathogenesis, genetics, and diagnosis of PH

  • causes of the condition, such as idiopathic pulmonary arterial hypertension (IPAH)

  • PAH-complicating connective tissue diseases (CTD), congenital heart diseases, human immunodeficiency virus (HIV), and other disorders

  • the mechanisms, toxicities, and efficacy of therapeutic agents

  • the role of combination therapies, novel agents, and future directions

  • PH in specific patient populations such as pregnant and critically-ill patients in the ICU


Classification, Epidemiology, Pathology, Pathogenesis and Genetics
Updated Clinical Classification of Pulmonary Hypertension Ivan M. Robbins and Ge´rald Simonneau
Epidemiology of Pulmonary Arterial Hypertension Marc Humbert
Pathology of Pulmonary Hypertension Peter Dorfmu¨ ller
Pathogenesis of Pulmonary Hypertension Norbert F. Voelkel, Lori Sweeney, and Herman Bogaard
Animal Models of Pulmonary Hypertension Laurence Dewachter and Robert Naeije
Genetics of PAH Eric D. Austin, James E. Loyd, and John A. Phillips III

Imaging and Diagnosis of Pulmonary Hypertension
Imaging of Pulmonary Hypertension Dominique Musset and Sophie Maıˆtre
Echocardiography of Pulmonary Arterial Hypertension Adam Torbicki and Anna Fijałkowska
Diagnosis and Hemodynamic Assessment of Pulmonary Arterial Hypertension Rajan Saggar, Rajeev Saggar, John A. Belperio, David A. Zisman, Joseph P. Lynch III, and Jamil Aboulhosn

Clinical Variants of Pulmonary Hypertension
Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension Jerome Le Pavec and Marc Humbert
Pulmonary Arterial Hypertension Complicating Connective Tissue Diseases Paul M. Hassoun
Pulmonary Arterial Hypertension in Congenital Heart Disease Daniel S. Levi, Victoria Scott, and Jamil Aboulhosn
Pulmonary Arterial Hypertension and Human Immunodeficiency Virus Infection Bruno Degano and Olivier Sitbon
Portopulmonary Hypertension Michael J. Krowka
Pulmonary Hypertension Complicating Schistosomiasis Caio J. C. S. Fernandes, Carlos Jardim, and Roge´rio Souza
Pulmonary Hypertension in Sickle Cell Disease Mark T. Gladwin
Pulmonary Veno-occlusive Disease and Pulmonary Capillary Hemangiomatosis David Montani
Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease Emmanuel Weitzenblum and Ari Chaouat
Pulmonary Hypertension Complicating Interstitial Lung Disease David A. Zisman, John A. Belperio, Rajan Saggar, Rajeev Saggar, Michael C. Fishbein, and Joseph P. Lynch III
Pulmonary Hypertension in Chronic Mountain Sickness Dante Penaloza and Francisco Sime
Chronic Thromboembolic Pulmonary Hypertension William R. Auger and Peter F. Fedullo

Medical Treatment of Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension: Conventional Therapy Olivier Sitbon
Medical Treatment of PAH: Prostacyclins Paul R. Forfia and Vallerie V. McLaughlin
Phosphodiesterase Type 5 Inhibitors Nazzareno Galie`
Medical Treatment of Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
Kristina Kemp and Marc Humbert
Medical Treatment of PAH: Combination Therapy, Novel Agents, Future Directions, and
Current Recommendations Lewis J. Rubin and Sean P. Gaine
Goal-Oriented Therapy in Pulmonary Arterial Hypertension Marius M. Hoeper

Atrioseptostomy and Surgery for Pulmonary Hypertension
Atrial Septostomy for the Treatment of Severe Pulmonary Hypertension Julio Sandoval, Jorge Gaspar, and Toma´s Pulido
Surgical Management of Pulmonary Hypertension Philippe G. Dartevelle, Elie Fadel, Sacha Mussot, Dominique Fabre, Olaf Mercier, Marc Humbert, and Ge´rald Simonneau
The Selection and Timing of Transplantation for Patients with Pulmonary Arterial Hypertension Paul A. Corris

Difficult Pulmonary Hypertension
Pulmonary Arterial Hypertension and Pregnancy Xavier Jai¨s, Laura Claire Price, Florence Parent, and Marc Humbert
Pediatric Pulmonary Hypertension Cecile Tissot and Maurice Beghetti
Practical Management of Pulmonary Arterial Hypertension in the Intensive Care Unit Benjamin Sztrymf and Marc Humbert

Endpoints and Clinical Trials
End Points and Clinical Trial Design in Pulmonary Arterial Hypertension: Clinical and Regulatory Perspectives Andrew J. Peacock


ISBN-13: 9781420094763
Publisher: Taylor & Francis (CRC Press)
Publication date: July, 2009
Pages: 526