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Protein Therapeutics
2 Volume Set
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Main description:

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades.
Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.


Contents:

Contents to Volume 1
Preface XVII
A Personal Foreword XXI
Acknowledgements XXIII
Part I Introduction to Protein Therapeutics: Past and Present 1
1 Early Recombinant Protein Therapeutics 3Pierre De Meyts
2 Evolution of Antibody Therapeutics 25Herve Watier and Janice M. Reichert
Part II Antibodies: The Ultimate Scaffold for Protein Therapeutics 51
3 Human Antibody Structure and Function 53Ponraj Prabakaran and Dimiter S. Dimitrov
4 Antibodies from Other Species 85Melissa L. Vadnais, Michael F. Criscitiello, and Vaughn V. Smider
Part III Discovery and Engineering of Protein Therapeutics 113
5 Human Antibody Discovery Platforms 115William R. Strohl
6 Beyond Antibodies: Engineered Protein Scaffolds for Therapeutic Development 161Nishant K. Mehta and Jennifer R. Cochran
7 Protein Engineering: Methods and Applications 189Claire Dobson
8 Bispecifics 229Jijie Gu, Andrew McCluskey, and Tariq Ghayur
9 Antibody drug Conjugates (ADCs) 271Dr Philip W. Howard
Contents to Volume 2
Preface XVII
A Personal Foreword XXI
Acknowledgements XXIII
Part IV Physiological and Manufacturing Considerations for Biologics 311
10 Pharmacokinetics of Therapeutic Proteins 313Zheng Lu, Jennifer Sheng, and Wenhui Zhang
References 334
11 Safety Considerations for Biologics 341Maggie Dempster, Lucinda R. Weir, and Rajni S. Fagg
12 Immunogenicity of Biologics 387Matthew P. Baker, Timothy D. Jones, and Paul Chamberlain
13 Expression Systems for Recombinant Biopharmaceutical Production by Mammalian Cells in Culture 423Adam J. Brown, Devika Kalsi, Alejandro Fernandez-Martell, Joe Cartwright, Nicholas O. W. Barber, Yash D. Patel, Richard Turner, Claire L. Bryant, Yusuf B. Johari, and David C. James
Abbreviations 450
References 452
14 Stability, Formulation, and Delivery of Biopharmaceuticals 469Hanns-Christian Mahler and Andrea Allmendinger
Part V Clinical Applications 493
15 Protein Therapeutics in Autoimmune and Inflammatory Diseases 495Anthony J. Coyle and Leigh S. Zawel
References 511
16 Antibody-Based Therapeutics in Oncology 521Paul A. Moore, Ross La Motte-Mohs, Jonathan C. Li, and Gurunadh R. Chichili
17 Protein Therapeutics in Respiratory Medicine 587 Rahul Shrimanker and Ian D. Pavord
18 Antibodies for the Prevention, Treatment, and Preemption of Infectious Diseases 611Steve Projan
19 Rescue Therapies 621Stephan Glund
20 Biosimilars 645Jun Wang
Part VI Future Horizons 661
21 Future Horizons and New Target Class Opportunities 663Herren Wu, Carl Webster, Judy Paterson, Sandrine Guillard, Ron Jackson, and Ralph Minter
References 690
Index 701


PRODUCT DETAILS

ISBN-13: 9783527699148
Publisher: John Wiley & Sons Ltd (Wiley-VCH Verlag GmbH)
Publication date: September, 2017
Pages: 752

Subcategories: Pharmacology