This book contains the refereed contributions from the 43rd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. ISOTT conferences are a place where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The proceedings include sessions covered various research topics including Multi-Modal Imaging/Spectroscopy & Instrumentation; Cancer Metabolism; Cellular Hypoxia and Mitochondrial Function; Brain Oxygenation and Function; Other Organ Function and Metabolism; Oxygen Transport in Sports, Diseases and Clinical Care; Acupuncture, Meridians, and Primo Vascular System; EPR, MRS and MRI.
1. ISOTT from the Beginning: A Tribute to Our Deceased Members (Icons)D. F. Bruley and E. E. ThiessenPart I Cell Metabolism, Tissue Oxygenation and Treatment2. A Compelling Case for the Use of Perioperative Zymogen Protein C for Increased Patient Safety D. F. Bruley, J. M. Abdallah, M. B. Streiff, T. W. McGuire, K. C. Bruley, M. Duncan, R. Duncan, E. E. Thiessen, M. White, K. C. Bruley, Jr., and S. B. Bruley3. Clinical Evaluation of MP4CO: A Phase 1b Escalating-dose, Safety and Tolerability Study in Stable Adult Patients with Sickle Cell Disease Peter E. Keipert4. Protective Effect of Dl-3-n-butylphthalide on Recovery from Cardiac Arrest and Resuscitation in Rats Le Zhang, Michelle A. Puchowicz, Joseph C. LaManna, and Kui Xu5. Hypoxia-Induced Let-7d Has a Role in Pericyte Differentiation Nilufer Esen, Anuush Vejalla, Rakhi Sharma, Jesse S. Treuttner, and Paula Dore-Duffy6. Magnification of Cholesterol-Induced Membrane Resistance on the Tissue Level: Implications for Hypoxia Ryan Shea, Casey Smith, and Sally C. Pias7. Respiratory Pores on Ostrich Struthio camelus (Aves: Struthionidae) Eggshells T. Koyama and A.J.D. Tennyson 8. Evaluation of both Free Radical Scavenging Capacity and Antioxidative Damage Effect of Polydatin Ju Jin, Yan Li, Xiuli Zhang, Tongsheng Chen, Yifei Wang, and Zhiping Wang9. Spectroscopic Studies on the Interaction of Pyridinoline Cross-linking in Type 1 Collagen with ZIF8-HB Yashun Chen, Fangfang He, Wei Liu, and Jucheng Zhang10. The Role of Free Radicals in the Photodynamic Treatment of Fibrotic Skin Diseases Heping Yan, Yashun Chen, Jucheng Zhang, Wei Liu, and Rui ChenPart II Cancer Oxygenation and Metabolism11. Tumor Hypoxia: Causative Mechanisms, Microregional Heterogeneities, and the Role of Tissue-based Hypoxia Markers Peter Vaupel and Arnulf Mayer12. Molecular Imaging of Tumor Hypoxia: Existing Problems and Their Potential Model-based Solutions Kuangyu Shi, Sibylle I. Ziegler, and Peter Vaupel13. Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications Harold M. Swartz, Benjamin B. Williams, Huagang Hou, Nadeem Khan, Lesley A. Jarvis, Eunice Y. Chen, Philip E. Schaner, Arif Ali, Bernard Gallez, Periannan Kuppusamy, and Ann B. Flood14. Impact of the Tumor Microenvironment on the Expression of Inflammatory Mediators in Cancer Cells A. Riemann, A. Ihling, S. Reime, M. Gekle, and O. Thews15. Comparing the Effectiveness of Methods to Measure Oxygen in Tissues for Prognosis and Treatment of Cancer Ann Barry Flood, Victoria A. Satinsky, and Harold M. Swartz16. Potential Indexing of the Invasiveness of Breast Cancer Cells by their Mitochondrial Redox RatiosNannan. Sun, He N. Xu, Qingming. Luo, and Lin Z. Li17. Directional Migration of MDA-MB-231 Cells under Oxygen Concentration GradientsD. Yahara, T. Yoshida, Y. Enokida, and E. Takahashi18. Stress-induced Stroke and Stomach Cancer: Sex Differences in Oxygen Saturation Maria Ulanova, Artem Gekalyuk, Ilana Agranovich, Victoria Rezunbaeva, Ekaterina Borisova, Aly Esmat Sharif, and Oxana Semyachkina-GlushkovskayaPart III Brain Oxygenation and Function19. Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature InfantsAlexander Caicedo, Liesbeth Thewissen, Anne Smits, Gunnar Naulaers, Karel Allegaert, and Sabine Van Huffel20. Effects of Positive and Negative Mood Induction on the Prefrontal Cortex Activity measured by Near Infrared Spectroscopy A. Compare, A. Brugnera, R. Adorni, and K. Sakatani21. Correlation between the Cerebral Oxyhaemoglobin Signal and Physiological Signals during Cycling Exercise: A Near-Infrared Spectroscopy Study Atsuhiro Tsubaki, Haruna Takai, Keiichi Oyanagi, Sho Kojima, Yuta Tokunaga, Shota Miyaguchi, Kazuhiro Sugawara, Daisuke Sato, Hiroyuki Tamaki, and Hideaki Onishi22. Effect of Locomotor Respiratory Coupling Induced by Cortical Oxygenated Hemoglobin Levels during Cycle Ergometer Exercise of Light Intensity Keiichi Oyanagi, Atsuhiro Tsubaki, Yuichi Yasufuku, Haruna Takai, Takeshi Kera, Akira Tamaki, Kentaro Iwata, and Hideaki Onishi23. Hypoxia and Neonatal Haemorrhagic Stroke: Experimental Study of Mechanisms Oxana Semyachkina-Glushkovskaya, Ekaterina Borisova, Anton Namikin, Ivan Fedosov, Arkady Abdurashitov, Ekaterina Zhinchenko, Artem Gekalyuk, Maria Ulanova, Victoria Rezunbaeva, Latchezar Avramov,Dan Zhu, Qingming Luo, and Valery Tuchin24. Interrelationship between Broadband NIRS Measurements of Cerebral Cytochrome C Oxidase and Systemic Changes Indicates Injury Severity in Neonatal EncephalopathyGemma Bale, Subhabrata Mitra, Isabel de Roever, Marcus Chan, Alexander Caicedo-Dorado, Judith Meek, Nicola Robertson, and Ilias Tachtsidis25. PFC Activity Pattern during Verbal WM Task in Healthy Male and Female Subjects: A NIRS StudyChenyang Gao, Lei Zhang, Dewu Luo, Dan Liu, and Hui Gong26. Spatial Distribution of Changes in Oxidised Cytochrome C Oxidase during Visual Stimulation using Broadband Near Infrared Spectroscopy Imaging P. Phan, D. Highton, S. Brigadoi, I. Tachtsidis, M. Smith, and C.E. Elwell27. Effects of Physical Exercise on Working Memory and Prefrontal Cortex Function in Post-Stroke Patients M. Moriya, C. Aoki, and K. Sakatani28. Relation between Prefrontal Cortex Activity and Respiratory Rate during Mental Stress Tasks: A Near-Infrared Spectroscopic Study Yuta Murayama, Lizhen Hu, Kaoru Sakatani29. Effects of Antioxidant Supplements (BioPQQTM) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex Masahiko Nakano, Yuta Murayama, Lizhen Hu, Kazuto Ikemoto, Tatsuo Uetake, and Kaoru Sakatani30. Temporal Comparison between NIRS and EEG Signals during a Mental Arithmetic Task Evaluated with Self-Organizing Maps Katsunori Oyama and Kaoru Sakatani31. The Role of Phonological Processing in Semantic Access of Chinese Characters: A Near-Infrared Spectroscopy Study Jinyan Sun, Linshang Rao, Chenyang Gao, Lei Zhang, Lan Liang, and Hui Gong32. Improvement of Impaired Cerebral Microcirculation using Rheological Modulation by Drag-Reducing Polymers D.E. Bragin, Z. Peng, O.A. Bragina, G.L. Statom, M.V. Kameneva, and E.M. Nemoto33. Relationship between Cerebral Oxygenation and Metabolism during Rewarming in Newborn Infants after Therapeutic Hypothermia following Hypoxic-ischemic Brain InjurySubhabrata Mitra, Gemma Bale, Judith Meek, Cristina Uria-Avellanal, Nicola J Robertson and Ilias TachtsidisPart IV Muscle Oxygenation and Sport Medicine34. Low Volume Aerobic Training Heightens Muscle Deoxygenation in Early Post-Angina Pectoris Patients Shun Takagi, Norio Murase, Ryotaro Kime, Masatsugu Niwayama, Takuya Osada, and Toshihito Katsumura35. The Effects of Passive Cycling Exercise for Twenty Minutes on Cardiorespiratory Dynamics in Healthy Men Sayuri Fuse, Ryotaro Kime, Takuya Osada, Norio Murase, and Toshihito Katsumura36. Regional Differences of Metabolic Response during Dynamic Incremental Exercise by 31P- CSIYasuhisa Kaneko, Ryotaro Kime, Yoshinori Hongo, Yusuke Ohno, Ayumi Sakamoto and Toshihito Katsumura37. Muscle Deoxygenation and Its Heterogeneity Changes after Endurance Training Ryotaro Kime, Masatsugu Niwayama, Yasuhisa Kaneko, Shun Takagi, Sayuri Fuse, Takuya Osada, Norio Murase, and Toshihito Katsumura38. Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1Î± mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle Fang-Hui Li, Hai-Tao Yu, Lin Xiao, and Yan-Ying Liu 39. Muscle Oxygen Dynamics during Cycling Exercise in Angina Pectoris Patients Shun Takagi, Norio Murase, Ryotaro Kime, Masatsugu Niwayama, Takuya Osada, and Toshihito KatsumuraPart V Acupuncture, Meridians, and Primo Vascular System40. Chronological Review on Scientific Findings of Bonghan System and Primo Vascular SystemKyung A Kang41. Temporal Change of Alcian Blue-Stained Primo Vascular System in Lymph Vessels of RatJungdae Kim, Dong-Hyun Kim, Sharon Jiyoon Jung, and Kwang-Sup Soh42. Ultrastructure of the Subcutaneous Primo-vascular System in Rat Abdomen Chae Jeong Lim, So Yeong Lee, and Pan Dong Ryu43. Effects of Acupuncture Stimulation on Muscle Tissue Oxygenation at Different PointsYasuhisa Kaneko, Ryotaro Kime, Eiji Furuya, Ayumi Sakamoto, and Toshihito KatsumuraPart VI Technologies and Modeling44. Comparison of CWS and Diffusion Theory for Quantification of Optical Properties: Fitting with Multi-Distance vs Multi-Wavelength Data Yung-Chi Lin, Zhi-Fong Lin, Shoko Nioka, Li-Hsin Chen, Sheng-Hao Tseng, and Pau-Choo Chung45. Multi-modality Optical Imaging of Rat Kidney Dysfunction: In vivo Response to Various Ischemia Times Zhenyang Ding, Lily Jin, Hsing-Wen Wang, Qinggong Tang, Hengchang Guo, and Yu Chen46. Skeletal Muscle Oxygenation Measured by EPR Oximetry using a Highly Sensitive Polymer-encapsulated Paramagnetic Sensor H. Hou, N. Khan, M. Nagane, S. Gohain, E. Y. Chen, L. A. Jarvis, P. E. Schaner, B. B. Williams, A. B. Flood, H. M. Swartz, and P. Kuppusamy47. Determination of Optical and Microvascular Parameters of Port Wine Stains Using Diffuse Reflectance Spectroscopy Zhihai Qiu, Guangping Yao, Defu Chen, Ying Wang, Ying Gu, and Buhong Li48. EPR Oximetry for Investigation of Hyperbaric O2 Pre-treatment for Tumor RadiosensitizationBenjamin B. Williams, Huagang Hou, Rachel Coombs, and Harold M. Swartz49. Design of a Compact, Bimorph Deformable Mirror-based Adaptive Optics Scanning Laser Ophthalmoscope Yi He, Yuanyuan Wang, Ling Wei, Xiqi Li, Jinsheng Yang, Guohua Shi, and Yudong Zhang50. Development of Portable, Wireless and Smartphone Controllable Near-Infrared Spectroscopy System Takashi Watanabe, Rui Sekine, Toshihiko Mizuno, and Mitsuharu Miwa51. Monitoring the Oxygen Dynamics of Brain Tissue in vivo by Fast Acousto-Optic Scanning Microscopy: A Proposed Instrument Zhenqiao Zhou, Dayu Chen, Zhiqiang Huang, Shaofang Wang, and Shaoqun Zeng52. Magnetization Transfer MRI Contrast May Correlate with Tissue Redox State in Prostate CancerRongwen Tain, He N. Xu, Xiaohong J. Zhou, Lin Z. Li, and Kejia Cai53. Comparison of Two Algorithms for Analysis of Perfusion Computed Tomography Data for Evaluation of Cerebral Microcirculation in Chronic Subdural Hematoma Alexey O. Trofimov, George Kalentiev, Oleg Voennov, Michail Yuriev, Darya Agarkova, Svetlana Trofimova, and Denis E. Bragin54. MMP-14 Triggered Fluorescence Contrast Agent Mai-Dung Nguyen and Kyung A. Kang<55. Boundary Element Method for Reconstructing Absorption and Diffusion Coefficients of Biological Tissues in DOT/MicroCT Imaging Wenhao Xie, Yong Deng, Lichao Lian, Dongmei Yan, Xiaoquan Yang, and Qingming Luo56. Mathematical Model of an Innate Immune Response to Cutaneous Wound in the Presence of Local Hypoxia Guennadi Saiko, Karen Cross, and Alexandre Douplik57. Analytical Expression for the NO Concentration Profile Following NONOate Decomposition in the Presence of Oxygen Zimei Rong and Zhihui Ye