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Oxidative Stress and Antioxidant Protection
The Science of Free Radical Biology and Disease
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Main description:

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and< Disease provides an overview of the basic principles of free radical formation. The text delves into free radical formation in molecular biology and its effect on subcellular damage, as well as the role of antioxidant reserves as a protective mechanism.
Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology.
Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.


List of Contributors ix
Special Recognition xiii
Foreword xv
Preface xvii
Section 1: Introduction
1 Introduction to Free Radicals, Inflammation, and Recycling 3 Donald Armstrong
2 Diagnostic Imaging and Differential Diagnosis 11 Robert D. Stratton
Section 2: Clinical Correlations on Acute and Chronic Diseases
3 Free Radicals: Their Role in Brain Function and Dysfunction 23 Natan Gadoth
4 Mediators of Neuroinflammation 39 Rajiv Tikamdas, Ping Zhang, and Bin Liu
5 Oxidative and Nitrative Stress in Schizophrenia 57 Anna Dietrich-Muszalska
6 The Effects of Hypoxia, Hyperoxia, and Oxygen Fluctuations on Oxidative Signaling in the Preterm Infant and on Retinopathy of Prematurity 77 M. Elizabeth Hartnett
7 Oxidative Damage in the Retina 93 Robert D. Stratton
8 The Role of Oxidative Stress in Hearing Loss 115 Colleen G. Le Prell and Josef M. Miller
9 Disorders of Children 133 Hirokazu Tsukahara and Masato Yashiro
10 Oxidative Stress in Oral Cavity: Interplay between Reactive Oxygen Species and Antioxidants in Health, Inflammation, and Cancer 155 Maurizio Battino, Maria Greabu and Bogdan Calenic
11 Oxidative Stress and the Skin 167 Christina L. Mitchell
12 Oxidative Stress in Osteoarticular Diseases 183 Maria Jose Alcaraz, Sergio Portal-Nunez, Juan A. Ardura and Pedro Esbrit
13 Gene Therapy to Reduce Joint Inflammation in Horses 193 Patrick Colahan, Rachael Watson, and Steve Ghivizzani
14 Muscle and Oxidative Stress 205 Reza Ghiasvand and Mitra Hariri
15 Role of Oxidants and Antioxidants in Male Reproduction 221 Ashok Agarwal, Hanna Tadros, Aaron Panicker and Eva Tvrda
16 Role of Oxidants and Antioxidants in Female Reproduction 253 Ashok Agarwal, Hanna Tadros and Eva Tvrda
17 Reactive Oxygen Species, Oxidative Stress, and Cardiovascular Diseases 281 Fatemeh Sharifpanah and Heinrich Sauer
18 Oxidative Stress and Antioxidant Imbalance: Respiratory Disorders 307 Surinder K. Jindal
19 Oxidative Stress and Type 1 Diabetes 319 Chao Liu, Clayton E. Mathews, and Jing Chen
20 Metabolic Syndrome, Inflammation, and Reactive Oxygen Species in Children and Adults, 329 William E. Winter and Janet H. Silverstein
21 Oxidative Stress in Chronic Pancreatitis 339 Shweta Singh and Bechan Sharma
22 Wound Healing and Hyperbaric Oxygen Therapy Physiology: Oxidative Damage and Antioxidant Imbalance 347 James R. Wilcox and D. Scott Covington
23 Radiobiology and Radiotherapy 357 Justin Wray and Judith Lightsey
24 Chemotherapy-Mediated Pain and Peripheral Neuropathy: Impact of Oxidative Stress and Inflammation 367 Hassan A.N. El-Fawal, Robert Rembisz, Ryyan Alobaidi, and Shaker A. Mousa
25 Grape Polyphenol-rich Products with Antioxidant and Anti-inflammatory Properties 389 Eduarda Fernandes, Marisa Freitas, Renan C. Chiste, Elena Falque, and Herminia Dominguez
26 Isotonic Oligomeric Proanthocyanidins 403 Hanbo Hu and Donald Armstrong
27 Superoxide Dismutase Mimics and Other Redox-active Therapeutics 415 Ines Batinic-Haberle and Artak Tovmasyan
28 Herbal Medicine: Past, Present, and Future with Emphasis on the Use of Some Common Species 471 Aneela Afzal and Mohammad Afzal
29 Ayurvedic Perspective on Oxidative Stress Management 483 Priyanka M. Jadhav
30 Clinical Trials and Antioxidant Outcomes 493 Carlos Palacio and Arshag D. Mooradian
31 Statistical Approaches to Make Decisions in Clinical Experiments 507 Albert Vexler and Xiwei Chen
Index 561


ISBN-13: 9781118832370
Publisher: John Wiley & Sons Ltd (John Wiley & Sons Inc)
Publication date: December, 2016
Pages: 500
Dimensions: 150.00 x 250.00 x 33.00

Subcategories: Biochemistry, Gastroenterology