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Osteogenesis Imperfecta
A Translational Approach to Brittle Bone Disease
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Main description:

Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI.


Contents:

Foreword Acknowledgments List of Contributors Section 1: INTRODUCTION Section 2: BONE BIOLOGY, STRUCTURE AND BIOCHEMISTRY Section 3: CLINICAL AND MOLECULAR GENETICS OF OSTEOGENESIS IMPERFECTA Section 4: COL1A1 AND COL1A2 MUTATIONS Section 5: ANIMAL MODELS OF OSTEOGENESIS IMPERFECTA Section 6: BRITTLE BONE OVERLAP PHENOTYPES: TGF-BETA MUTATIONS AND BONE Section 7: CLINICAL ASPECTS OF OSTEOGENESIS IMPERFECTA Section 8: ORGAN INVOLVEMENT IN OSTEOGENESIS IMPERFECTA Chapter 9: ORTHOPEDICS Section 10: PHYSICAL MEDICINE AND REHABILITATION Section 11: PHARMACOLOGIC TREATMENT OF OSTEOGENESIS IMPERFECTA Section 12: GENETIC APPROACH TO TREATMENT OF OSTEOGENESIS IMPERFECTA Index


PRODUCT DETAILS

ISBN-13: 9780123977892
Publisher: Elsevier (Academic Press Inc)
Publication date: September, 2013
Pages: 772

Subcategories: Endocrinology, Orthopaedics and Fractures, Physiology