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Noninvasive Molecular Markers in Gynecologic Cancers
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Main description:

Early detection is critical for any given cancer. With the advent of the latest omics technologies, molecular markers in combination with conventional diagnostic and screening methods are emerging as next-generation early diagnostic and prognostic strategies that can allow early-stage diagnosis, resulting in more effective treatment and patient care and, in turn, an increased rate of survival. A ready-made resource, Noninvasive Molecular Markers in Gynecologic Cancers not only provides information on noninvasive molecular diagnostic biomarkers, it includes coverage of the epidemiology, clinical features, conventional diagnosis, treatment, and prognosis for these cancers. With contributions from leading international experts, the book presents a compact but comprehensive overview of gynecologic cancer. Each of the five main gynecologic cancers-ovarian, cervical, uterine, vaginal, and vulvar-have unique signs and symptoms, risk factors, and molecular profile, and therefore requires different prevention strategies. This book describes the different features of each gynecologic cancer in separate chapters covering general information, epidemiology, clinical features, and biomarkers.
The book also covers breast cancer and, although rare, fallopian tube cancer, to make it a complete resource. In cancer treatment, non-invasive diagnosis can avoid complications of biopsy and other unfavorable impacts on patients' health. DNA, methylation, SNPs, miRNA, mRNA, protein, autoantibodies, metabolite, and omics-based markers from remote media such as blood, plasma, and urine are emerging as noninvasive molecular markers with high specificity and sensitivity towards many cancers. This book classifies the available molecular tumor markers according to their principal characteristics and relative methodologies. It covers markers that not only provide early detection and better treatment options, but are emerging as next-generation personalized diagnostics and targets or therapeutics for personalized cancer treatment.


GENERAL Overview of Gynecologic Cancers Ikbal Kaygusuz, Aydin Kosus, and Hasan Kafali Cytogenetic Early Markers in Gynecologic Cancers Murat Oznur, Serap Dede, Debmalya Barh, and Mehmet Gunduz BREAST CANCER Early Biomarkers in Breast Cancer Ruchika Kaul-Ghanekar, Snehal Suryavanshi, and Prerna Raina Diagnostic and Prognostic Markers of Breast Invasive Lesions Maria C. Calomarde, Carlos Iglesias, Elisa Moreno-Palacios, Javier De Santiago, and Ignacio Zapardiel Biomarkers for Early Detection of Familial Breast Cancer Burak Yilmaz, Catherine A. Moroski-Erkul, Omer Faruk Hatipoglu, Esra Gunduz, Debmalya Barh, and Mehmet Gunduz DNA Methylation: An Epigenetic Marker of Breast Cancer Influenced by Nutrients Acting as an Environmental Factor Tarique N. Hasan, Gowhar Shafi, B. Leena Grace, Jesper Tegner, and Anjana Munshi CERVICAL CANCER Biomarkers for Early Detection of Cervical Cancer Ruchika Kaul-Ghanekar, Amit S. Choudhari, and Savita Pandita Biomarkers in Cervical Cancer: DNA HR-HPV, p16INK4a, Ki-67, and RNA-m E6/E Maria Serrano, Maria-Dolores Diestro, Marcos Cuerva, Ignacio Zapardiel, Adolfo Loayza, Alicia Hernan, and Javier De Santiago Biomarkers of Nucleotide Metabolism in Cervical Cancer Charles A. Kunos, Lauren Shunkwiler, and Gina Ferris OVARIAN CANCER Noninvasive Early Biomarkers in Ovarian Cancer Sharon A. O'Toole, Eugen Ancuta, Ream Langhe, Dolores J. Cahill, Mairead Murphy, Cara Martin, Lynda McEvoy, Cathy Spillane, Orla Sheils, Emmanuel Petricoin, Lance Liotta, and John J. O'Leary Biomarkers in Ovarian Endometrioid Carcinoma Murat Oznur, Serap Memik, Mehmet Gunduz, and Esra Gunduz MUC16/CA125: A Candidate Tumor Marker for Diagnosis and Therapy in Ovarian Cancer Houda Bouanene and Jemni Ben Chibani Role of He4 in the Management of Ovarian Cancer Daniel Abehsera, Javier De Santiago, and Ignacio Zapardiel UTERINE AND FALLOPIAN TUBE CANCERS Biomarkers in Endometrial Cancer Gokhan Nas, Tugce Yasar, Mehmet Gunduz, and Esra Gunduz Biomarkers in Uterine Mesenchymal and Mixed Malignant Tumors Rosario Rivera Buery and Esra Gunduz Noninvasive Early Biomarkers in Fallopian Tube Carcinoma Panagiotis Peitsidis VAGINAL AND VULVAR CANCERS Biomarkers for Early Detection of Vaginal Cancers Zeynep Ocak, Muradiye Acar, Mehmet Gunduz, and Esra Gunduz Noninvasive Early Biomarkers for Vulvar Cancer Sara Iacoponi, Marcos Cuerva, Mar Gil, Elisa Moreno-Palacios, Alicia Hernan, Javier De Santiago, and Ignacio Zapardiel


ISBN-13: 9781466569393
Publisher: Taylor & Francis (CRC Press Inc)
Publication date: January, 2015
Pages: 504