Pharmacological approaches to our understanding of sleep have been at the forefront of sleep research for many years. Traditional techniques have included the use of pharmacological agonists and antagonists, as well as transmitter-specific lesions. These have been enhanced by the introduction of molecular genetics and the use of transgenes and targeted gene deletion. Neurochemistry of Sleep and Wakefulness is an exceptional, single source of information on the role of the major mammalian neurotransmitter systems involved in the regulation of sleep and waking. With contributions from internationally recognized experts, this book clearly describes how researchers have made use of the myriad techniques in their armamentarium to characterize the role of a given neurotransmitter in the regulation of sleep and waking. Suitable for experimental and clinical pharmacologists, the book will have wider appeal to sleep researchers, psychiatrists and any professional interested in the interdisciplinary areas of neurobiology and pharmacology.
Part I. The Neurochemistry of the States of Sleep and Wakefulness: 1. Neurochemistry of the preoptic hypothalamic hypnogenic mechanism Dennis McGinty, Md. Noor Alam, Hui Gong, Melvi Methippara, Natalia Suntsova, Ruben Guzman-Marin and Ronald Szymusiak; 2. Neuroanatomical and neurochemical basis of wakefulness and REM sleep systems Ritchie E. Brown and Robert W. McCarley; 3. Rapid eye movement sleep regulation by modulation of the noradrenergic system Birendra N. Mallick, Vibha Madan and Sushil K. Jha; Part II. The Influence of Neurotransmitters on Sleep and Wakefulness: 4. Gamma-aminobutyric acid and the regulation of paradoxical, or rapid eye movement sleep Pierre-Hervé Luppi, Damien Gervasoni, Laure Verret, Romain Goutagny, Christelle Peyron, Denise Salvert, Lucienne Leger and Patrice Fort; 5. Acetylcholine modulates sleep and wakefulness: a synaptic perspective Ralph Lydic and Helen A. Baghdoyan; 6. Histamine in the control of sleep-wakefulness Mahesh M. Thakkar and Robert W. McCarley; 7. Dopamine in behavioral state control David B. Rye and Amanda A. H. Freeman; 8. Glutamate neurotransmission and sleep Irwin Feinberg and Ian G. Campbell; 9. Serotonin and sleep/wake regulation Jaime M Monti, Héctor Jantos and Daniel Monti; Part III. Changing Perspectives: 10. Melatonin and its receptors: biological function in circadian sleep/wake regulation Daniel P. Cardinali, S. R. Pandi-Perumal and Lennard P. Niles; 11. Sleep regulatory factors Levente Kapás and Éva Szentirmai; 12. Adenosine and sleep/wake regulation Dag Stenberg and Tarja Porkka-Heiskanen; 13. Prostaglandins and the regulation of sleep and wakefulness Osamu Hayaishi and Yoshihiro Urade; 14. Neuropeptides and sleep/wake regulation Luis de Lecea; 15. Orexins in sleep and wakefulness: rodent models of narcolepsy-cataplexy Christopher M. Sinton and Jon T. Willie; 16. The relevance of experimental pharmacology to currently available sleep/wake therapeutics Rafael J. Salin-Pascual.