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Natural Products in Chemical Biology
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Main description:

A timely and authoritative look at the chemistry of natural products


Based on the acclaimed Wiley Encyclopedia of Chemical Biology, this book focuses on natural products and explores their impact on drug discovery and design. With emphasis on the gamut of biological diversity and activities of natural products, the book examines the unique features of these molecules, highlights influences from genetics and biochemistry, and points to promising future trends. Divided into three parts, Natural Products in Chemical Biology first introduces sources of natural products, then goes on to present the biosynthesis of main classes of natural products and their uses in medicine. The book presents fourteen self–contained, peer–reviewed articles carefully selected from the Wiley Encyclopedia of Chemical Biology and new material. Clear, authoritative coverage includes:



  • A discussion of the chemical diversity of plant, marine, and microbial natural products

  • Biosynthesis of nonribosomal peptides, plant terpenoids, polyketides, alkaloids, cofactors, and antibiotics

  • Use of natural products and natural product models in the pharmaceutical industry


Natural Products in Chemical Biology is an excellent introduction to the ongoing research in the chemistry of natural products for researchers in diverse fields, from organic and medicinal chemistry to molecular biology and the pharmaceutical industry.


Back cover:

A timely and authoritative look at the chemistry of natural products


Based on the acclaimed Wiley Encyclopedia of Chemical Biology, this book focuses on natural products and explores their impact on drug discovery and design. With emphasis on the gamut of biological diversity and activities of natural products, the book examines the unique features of these molecules, highlights influences from genetics and biochemistry, and points to promising future trends. Divided into three parts, Natural Products in Chemical Biology first introduces sources of natural products, then goes on to present the biosynthesis of main classes of natural products and their uses in medicine. The book presents fourteen self–contained, peer–reviewed articles carefully selected from the Wiley Encyclopedia of Chemical Biology and new material. Clear, authoritative coverage includes:



  • A discussion of the chemical diversity of plant, marine, and microbial natural products

  • Biosynthesis of nonribosomal peptides, plant terpenoids, polyketides, alkaloids, cofactors, and antibiotics

  • Use of natural products and natural product models in the pharmaceutical industry


Natural Products in Chemical Biology is an excellent introduction to the ongoing research in the chemistry of natural products for researchers in diverse fields, from organic and medicinal chemistry to molecular biology and the pharmaceutical industry.


Contents:

Preface vii

Contributors ix


PART I CHEMICAL DIVERSITY OF NATURAL PRODUCTS 1


1 Plant Natural Products 3
A. Leslie Gunatilaka


2 Marine Natural Products 31
Nobuhiro Fusetani


3 Microbial Natural Products 65
Sergio Sanchez, Silvia Guzma´n–Trampe, MarianaA´valos, Beatriz Ruiz, Romina Rodr´ýguez–Sanoja, andManuel Jim´enez–Estrada


PART II BIOSYNTHESIS OF NATURAL PRODUCTS 109


4 Nonribosomal Peptides 111
Georg Schoenafinger and Mohamed A. Marahiel


5 Plant Terpenoids 127
Christopher I. Keeling and J¨org Bohlmann


6 Polyketides in Fungi 143
Thomas J. Simpson and Russell J. Cox


7 Modular Polyketide Synthases 163
Tonia J. Buchholz, Jeffrey D. Kittendorf, and David H.Sherman


8 Polyketide Polyethers 189
Alison M. Hill


9 Alkaloids 209
Sarah E. O Connor


10 Cofactors 239
Ilka Haase, Markus Fischer, Adelbert Bacher, WolfgangEisenreich, and Felix Rohdich


11 Antibiotics 269
Sergey B. Zotchev


PART III NATURAL PRODUCTS IN MEDICINE 287


12 Pharmaceuticals: Natural Products and Natural Product Models289
Sheo B. Singh


13 Natural Products as Anticancer Agents 325
David G. I. Kingston and David J. Newman


14 Plant–Derived Natural Products Research in Drug Discovery351
Kuo–Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama, and Susan L.Morris–Natschke


Index 389


PRODUCT DETAILS

ISBN-13: 9781118391822
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: July, 2012
Pages: 436
Dimensions: 155.00 x 238.00 x 27.18

Subcategories: Biochemistry, Diseases and Disorders

MEET THE AUTHOR

NATANYA CIVJAN, PhD, is a freelance editor with adoctorate in biochemistry. Formerly with John Wiley & Sons, shehas developed and edited the Wiley Encyclopedia of ChemicalBiology and was part of the team responsible for the WileyInterdisciplinary Reviews, which won top prizes in publishingfrom the American Publishers Awards for Professional and ScholarlyExcellence.