Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.
Prologue Jose L. Arias Key Aspects in Nanotechnology and Drug Delivery Jose L. Arias Drug Delivery and Release from Polymeric Nanomaterials Cornelia Vasile, Ana Maria Oprea, Manuela Tatiana Nistor and Anca-Maria Cojocariu Nano-Sized Polymeric Drug Carrier Systems Cornelia Vasile, Manuela Tatiana Nistor and Anca-Maria Cojocariu Reversible Cross-Linked Polymeric Nanoplatform in Drug Delivery Yuanpei Li, Kai Xiao and Kit S. Lam Cyclodextrins in Drug Delivery Nazli Erdogar and Erem Bilensoy Drug Delivery Systems Based on Tyrosine-derived Nanospheres (TyroSpheresTM) Zheng Zhang, Tannaz Ramezanli, Pei-Chin Tsai and Bozena B. Michniak-Kohn Carbon Nanotubes for Drug Delivery Applications Yitzhak Rosen and Pablo Gurman Metallic Nanoparticulate Drug Delivery Systems Varsha B. Pokharkar, Vividha V. Dhapte and Shivajirao S. Kadam Porous Silica Nanoparticles for Drug Delivery and Controlled Release Xiaoxing Sun and Brian G. Trewyn Iron Oxides in Drug Delivery Fahima Dilnawaz and Sanjeeb Kumar Sahoo Nanoengineered Magnetic Field-Induced Targeted Drug Delivery System with Stimuli Responsive Release R. Devesh K. Misra