This Brief focuses on the cancer therapy available till date, from conventional drug delivery to nanomedicine in clinical trial. In addition, it reports on future generation based nanotherapeutics and cancer theranostic agent for effective therapeutic diagnosis and treatment. Breast cancer was chosen as the model system in this review. The authors give emphasis to multiple drug resistance (MDR) and its mechanism and how to overcome it using the nanoparticle approach.
1. Conventional therapy for breast cancer- a brief overview of surgery, radiation, chemo and hormonal therapy advantage and disadvantage 2. Multiple drug resistance - Mechanism of drug resistance in details 3. Therapy to target multiple drug resistance - combinational approach to target MDR, combination of two drug molecules effectiveness calculation , combination of drug and biological molecule 4. Drug delivery through carrier or nanoformulation 5. Application of nanoformulation in cancer targeting 6. Gene Therapy -DNA and mRNA based therapy 7. Photodynamic therapy- mechanism , trials and success 8. Drug resistance and heat based therapy or Photothermal therapy - types of hyperthermia, hyperthermia heating instruments, cellular effect, nanoparticle ( gold, carbon and dye) based photothermal therapy, combination therapy with hyperthermia 9. Clinical trials success and challenge 10. Conclusion and future prospective