The ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and cellular biology, chemistry, physics, image analysis, and drug discovery to develop and translate promising approaches into reliable scientific applications and viable clinical diagnostic tools. Bringing together a select panel of internationally recognized authors, Molecular and Cellular MR Imaging provides a state-of-the-science overview of the multidisciplinary nature of the field and illustrates the application of these various sciences to investigate specific biological processes in animals and humans. Using a systematic organization to present diverse information, the text begins with an introductory chapter that defines cellular and molecular imaging and explains why magnetic resonance imaging (MRI) is the most versatile approach for noninvasive, in vivo studies.
The first section examines the physicochemical principles of various contrast agents including paramagnetic, superparamagnetic, CEST, and PARACEST agents, as well as smart and sensing agents. The second section summarizes the wide variety of applications for molecular imaging of genes and of disease states. Contributions cover cancer, apoptosis, cardiovascular and neurodegenerative disease, and the use of pharmacological MRI. The third section is devoted to cellular imaging under a variety of applications, and the final section discusses the translational aspects and future directions of cellular and molecular MR imaging. Molecular and Cellular MR Imaging highlights the diversity of skills required to translate advancements in various fields of research into practical applications that promise to revolutionize in vivo imaging as a diagnostic tool.
What Is Molecular and Cellular Imaging?, M.M. Modo and J.W.M. Bulte Contrast Agents for Molecular and Cellular Imaging Physicochemical Principles of MR Contrast Agents, P. Caravan Paramagnetic Contrast Agents, S. Aime, Z. Baranyai, E. Gianolio, and E. Terreno Superparamagnetic Contrast Agents, C. Corot, M. Port, I. Guilbert, P. Robert, I. Raynal, C. Robic, J.S. Raynaud, P. Prigent, A. Dencausse, and J.M. Idee Physical Mechanism and Applications of CEST Contrast Agents, M.T. McMahon, J. Zhou, A.A. Gilad, and P.C.M. van Zijl PARACEST Contrast Agents, A.D. Sherry and M. Woods Genetic Approaches for Modulating MRI Contrast, E. T. Ahrens, W. F. Goins, and C.S. Robison Molecular MR Imaging Molecular and Functional MR Imaging of Cancer, M. A. Jacobs, K. Glunde, B. Gimi, A. P. Pathak, E. Ackerstaff, D.Artemov, and Z. M. Bhujwalla Molecular Imaging of Atherosclerosis with Magnetic Resonance, K. C. Briley-Saebo, W.J. Mulder, F. Hyafil, V. Mani, V. Amirbekian, J. Gilberto, S. Aguinaldo, J. F. Rudd, S. H. Aguiar, and Z.A. Fayad Molecular Imaging of Apoptosis, M. I. Kettunen and K. M. Brindle Molecular Imaging of Reporter Genes, K. Ziv, D. Granot, V. Plaks, B. Cohen, and M. Neeman Pharmacological MRI as a Molecular Imaging Technique, Y. I. Chen and B. G. Jenkins Cellular MR Imaging Cellular MR Imaging of the Liver Using Contrast Agents, N. C. Balci and S. Mehmet Erturk Cellular Imaging of Macrophage Activity in Infection and Inflammation, M. Rausch, M. Rudin, P. Allegrini, and N. Beckmann Cellular Imaging of Macrophage Activity in Stroke, R. Weber and M. Hoehn Magnetic Resonance Imaging in Developmental Biology, C. Papan, J. M. Tyszka, and R. E. Jacobs Methods for Labeling Non-phagocytic Cells with MR Contrast Agents, J.A. Frank, S. A. Anderson, and A. S. Arbab Cellular Imaging of Cell Transplants, M.M.J.J. Modo and J.W.M. Bulte Cellular and Molecular Imaging of the Diabetic Pancreas, Z. Medarova and A. Moore Functional Cellular Imaging with Manganese, V. Van Meir and A. Van der Linden Future Perspectives for Molecular and Cellular Imaging Translating Promising Experimental Approaches to Clinical Trials, A. D. Nunn An Outlook on Molecular and Cellular MR Imaging, M. Modo and J. W.M. Bulte