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Minipig in Biomedical Research
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Main description:

The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors' global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig's origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered. The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices.
The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes 'How to' and 'Why' and 'What to expect in the normal', combining enthusiasm and experience with critical assessment of its values and potential problems.


Origin and Management of the Minipig History and Development of Miniature, Micro- and Minipigs Friederike Kohn (Germany) Husbandry and Management Roberta Scipioni Ball (USA) Diseases of Minipigs Nanna Grand (Denmark) International Transportation of Minipigs Finn Raaschou-Nielsen (Denmark) Welfare and Experimental Usage of the Minipig Ethical Issues in the Use of Minipigs in Animal Research David Morton (UK) Animal Welfare Issues M. Michael Swindle (USA), Alison C. Smith (USA), and Kathy E. Laber (USA) Stress in Experiments Larry Brown (USA) and L. Peter Gade (Denmark) Dosing Methods Peter Clausing (Germany) In-life Clinical Observations David Cameron (UK) Pharmacology and ADME Studies in the Minipig Minipigs in Absorption, Distribution, Metabolism and Excretion (ADME) Studies Cornelia Preusse (Germany) and Mette T. Skaanild (Denmark) Safety Pharmacology Stephane Milano (France) Safety Assessment in the Minipig - Principal Body Systems Dermal Toxicity Studies: Skin Architecture, Metabolism, Penetration and Toxicological and Pharmacological Methods Andy Makin (Denmark), Jens Thing Mortensen (Denmark), and Bill Brock (USA) Gastrointestinal Tract Chris Van Ginneken (Belgium) Heart and Cardiotoxicity James R. Turk (USA) Central and Peripheral Nervous Systems Alan D Rasmussen (Denmark) and Karen M. Wegener (Denmark) The Kidney Peter A. McAnulty (Denmark) Reproductive System including Studies in Juvenile Minipigs Paul Barrow (France), Edward Marsden (France), and Peter A. McAnulty (Denmark) The Endocrine System Claudia Stark (Germany) and Jakob Walter (Germany) Skeletal System Hideki Tsutsumi (Japan) Ocular Examination and Background Observations Helmut Ehall (UK) Spontaneous/Background Pathology of the Gottingen Minipig Mikala Skydsgaard (Denmark) and Zuhal Dincer (UK) Genetics and Immunology A Comparative Assessment of the Pig, Mouse, and Human Genomes: Structural and Functional Analysis of Genes Involved in Immunity and Inflammation Harry Dawson (USA) The Immune System of Pigs: Structure and Function Patrick Haley (USA) Allotransplantation in Miniature Swine John S. Hanekamp (USA), Raimon Duran-Struuck (USA), and David H. Sachs (USA) Xenotransplantation Henk-Jan Schuurman (USA), Melanie L. Graham (USA), Thomas Spizzo (USA), and Clive Patience (UK). Porcine endogenous retroviruses (PERVs) in xenotransplantation - A review of the importance of PERVs in porcine studies, with particular emphasis on the minipig Linda Scobie (UK) and Olga Garkavenko (New Zealand) Immunotoxicity Studies in Minipigs Andre Penninks (The Netherlands) and Geertje J.D. van Mierlo (The Netherlands) Disease Models Creation and conservation of genetically modified pigs: applications to genetic disease model and xenotransplantation Hiroshi Nagashima (Japan), Hitomi Matsunari (Japan), and Kazuhiro Umeyama (Japan) Stem Cell Research and Minipigs Vanessa J Hall (Denmark), Stoyan G Petkov (Denmark), and Poul Hyttel (Denmark) Minipig Models of Diabetes Mellitus Dwight A. Bellinger (USA), Elisabeth P. Merricks (USA), and Timothy C. Nichols (USA) Diet-induced Atherosclerosis James R. Turk (USA) and Maurice H. Laughlin (USA) Haemorrhage and Resuscitation Models Using Miniature Swine John Burns (USA) and Charles Wade (USA) Oral Biology and Dental Models Sue Herring (USA) , Yiming Li (USA), Yi Liu (USA), Professor Zi Jun Liu (USA), Tracy Popowics (USA), Katherine Rafferty (USA), and Songlin Wang (China) Osteoporosis Model in Minipigs Hideki Tsutsumi (Japan), Satoshi Ikeda (Japan) Toshitaka Nakamura (Japan) Wound Healing Models Peter Glerup (Denmark) The Minipig in Chemical, Biological and Radiological Warfare Research Stanley S. Hulet (USA), Maria Moroni (USA), Mark H Whitnall (USA), and Robert J Mioduszewski (USA) The Minipig and Pig in Medical Device Research Shayne C. Gad (USA) Regulatory Perspective and Use of the Minipig in Developing Marketed Products Regulatory Aspects - Pharmaceuticals, Medical Devices and Food Additives Abigail Jacobs (USA) and Jan-Willem van der Laan (The Netherlands) Adverse Responses to Drugs in Man: a critical comparison of reported toxicological findings in minipigs and humans Niels-Christian Ganderup (Denmark) Regulatory Acceptance of the Minipig in Non-Pharmaceutical Industry and Research Warren Harvey (UK) New Horizons and perspectives Future Prospects: Possibilities and Perspectives Anthony D. Dayan (UK)


ISBN-13: 9781439811191
Publisher: Taylor & Francis (CRC Press Inc)
Publication date: January, 2012
Pages: 662
Dimensions: 216.00 x 279.00 x 36.00