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Medical Biochemistry
Human Metabolism in Health and Disease
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Main description:

Helps Readers Understand The Link Between Metabolic Pathways And Human Health And Disease

Medical Biochemistry enables readers to master the essentials of human metabolism by explaining how metabolic pathways and reactions are connected to human health and disease. Rather than cover all the reactions that human cells and tissues are capable of executing, this text better enables readers to learn core concepts by emphasizing select examples that illustrate the physiologic and pathophysiologic significance of the major metabolic pathways. Designed for medical, dental, and allied health students and professionals, the text emphasizes clinically relevant information, helping readers understand the interrelationships between metabolic pathways and the links between metabolism and the causes, preventions, and cures for human diseases.


A separate chapter is dedicated to each of the key metabolic pathways that constitute human metabolism. Each chapter features a six–part structure that facilitates a clear understanding of the metabolic processes:



  • Major function(s) of the pathway


  • Tissues in which the pathway is active


  • Physiological conditions under which the pathway is most active


  • Reactions that comprise the pathway


  • Regulation of the pathway


  • Examples of human diseases related to the pathway



Throughout the text, simple figures help readers understand how metabolic pathways and reactions work.


This text′s concise, easy–to–follow approach helps readers understand and appreciate the functions, constituent reactions, and regulatory aspects of the core pathways that constitute human metabolism and are responsible for maintaining homeostasis and well–being in humans.


Back cover:

Helps Readers Understand The Link Between Metabolic Pathways And Human Health And Disease

Medical Biochemistry enables readers to master the essentials of human metabolism by explaining how metabolic pathways and reactions are connected to human health and disease. Rather than cover all the reactions that human cells and tissues are capable of executing, this text better enables readers to learn core concepts by emphasizing select examples that illustrate the physiologic and pathophysiologic significance of the major metabolic pathways. Designed for medical, dental, and allied health students and professionals, the text emphasizes clinically relevant information, helping readers understand the interrelationships between metabolic pathways and the links between metabolism and the causes, preventions, and cures for human diseases.


A separate chapter is dedicated to each of the key metabolic pathways that constitute human metabolism. Each chapter features a six–part structure that facilitates a clear understanding of the metabolic processes:



  • Major function(s) of the pathway


  • Tissues in which the pathway is active


  • Physiological conditions under which the pathway is most active


  • Reactions that comprise the pathway


  • Regulation of the pathway


  • Examples of human diseases related to the pathway



Throughout the text, simple figures help readers understand how metabolic pathways and reactions work.


This text′s concise, easy–to–follow approach helps readers understand and appreciate the functions, constituent reactions, and regulatory aspects of the core pathways that constitute human metabolism and are responsible for maintaining homeostasis and well–being in humans.


Contents:

PREFACE vii

ACKNOWLEDGMENTS ix


THE AUTHORS xi


1 INTRODUCTION TO METABOLISM 1


2 ENZYMES 11


3 DIGESTION AND ABSORPTION 38


4 GLYCOLYSIS 58


5 PYRUVATE DEHYDROGENASE AND THE TRICARBOXYLIC ACID CYCLE 77


6 ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION 89


7 THE PENTOSE PHOSPHATE PATHWAY 102


8 GLYCOGEN 112


9 GLUCONEOGENESIS 126


10 FATTY ACID OXIDATION AND KETONES 141


11 FATTY ACID SYNTHESIS 162


12 TRIACYLGLYCEROL TRANSPORT AND METABOLISM 177


13 ETHANOL 191


14 PHOSPHOLIPIDS AND SPHINGOLIPIDS 199


15 EICOSANOIDS 218


16 GLYCOLIPIDS AND GLYCOPROTEINS 231


17 CHOLESTEROL SYNTHESIS AND TRANSPORT 246


18 STEROIDS AND BILE ACIDS 271


19 NITROGEN HOMEOSTASIS 290


20 AMINO ACIDS 305


21 SULFUR AMINO ACID METABOLISM 325


22 FOLATE AND VITAMIN B12 IN ONE–CARBON METABOLISM 335


23 PURINES AND PYRIMIDINES 351


24 HEME AND IRON 372


25 INTEGRATION OF METABOLISM 393


INDEX 411


PRODUCT DETAILS

ISBN-13: 9780470560112
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: April, 2009
Pages: 440
Dimensions: 161.00 x 232.00 x 23.36

Subcategories: Biochemistry, Physiology

MEET THE AUTHOR

Miriam D. Rosenthal, PhD, is Professor of Biochemistry and Course Director for Medical Biochemistry at Eastern Virginia Medical School. Dr. Rosenthal has extensive experience teaching and developing curricula for both medical and allied health students.

Robert H. Glew, PhD, is Emeritus Professor of Biochemistry and Molecular Biology at the University of New Mexico Medical School. Dr. Glew has taught medical biochemistry at three medical schools in the United States and a medical school in West Africa.