The endothelium is an excellent example of where biology meets physics and engineering. It must convert mechanical forces into chemical signals to maintain homeostasis. It also controls the immune response, drug delivery through the vasculature, and cancer metastasis. Basic understanding of these processes is starting to emerge and the knowledge gained from research is now being used in applications from drug delivery to imaging modalities. This book reviews current knowledge in mechanobiology of the endothelium and its implications for the development of theranostic devices.
The Endothelium as a Mechanosensor Rachel E. Neubrander and Brian P. Helmke Mechanobiology of the Endothelial Nucleus Elizabeth A. Booth-Gauthier, Stephen Spagnol, Kris Noel Dahl Cancer Metastasis and Biomechanics of the Endothelium Claudia T. Mierke Valvular Endothelial Mechanobiology Suthan Srigunapalan and Craig A. Simmons Environmental Factors that Influence the Response of the Endothelium to Flow Tracy M. Cheung and George A. Truskey Differential Response of the Endothelium to Simultaneous Chemical and Mechanical Stimulation in Inflammation Response Ryan B. Huang and Omolola Eniola-Adefeso The Role of Cholesterol and Lipoproteins in Control of Endothelial Biomechanics Irena Levitan, Tzu-Pin Shentu, Mingzhai Sun, and Gabor Forgacs Implications of Fluid Shear Stress in Capillary Sprouting during Adult Microvascular Network Remodeling Walter L. Murfee Endothelial Cell Adhesion Molecules and Drug Delivery Applications Daniel Serrano and Silvia Muro Leukocyte Transendothelial Migration: A Biophysical Event Kimberly M. Stroka The Immune System as a Theranostic Device Janina A. Vaitkus and Helim Aranda-Espinoza