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Lysophospholipid Receptors
Signaling and Biochemistry
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Main description:

The current state of the science supporting new research inlysophospholipids


The study of lysophospholipids exploded with the discovery ofcell surface receptors on both lysophosphatidic acid (LPA) andsphingosine 1–phosphate (S1P). Since then, thousands of originalresearch reports ranging from fundamental cell signaling tothe physiology and pathophysiology of individual organsystems have centered on lysophospholipids. This book drawstogether and analyzes the current literature to provide readerswith a state–of–the–science review as well as current techniquesthat support research in all aspects of the field oflysophospholipid signaling.


Lysophospholipid Receptors is divided into threesections:



  • Receptors and other possible effectors

  • Enzymes

  • Physiology and pathophysiology


Within each section, the authors explain the similarities anddifferences between LPA and S1P signaling. Examples are providedthat demonstrate the underlying mechanisms of lysophospholipidsignaling across a broad range of organ systems, such as S1Psignaling in cardiovascular physiology and disease and the neuraleffects of LPA signaling. Extensive references at the end of eachchapter provide a gateway to the literature and facilitate furtherresearch into individual topics.


Each chapter has been authored by one or more leadinginternational authorities in lysophospholipid research. Based on athorough analysis of the current research, the authors set forthwhat is established science and offer their expert opinion andperspective on new and emerging areas of research, setting thestage for further investigations that will solve current problemsin the field.


Back cover:

The current state of the science supporting new research inlysophospholipids


The study of lysophospholipids exploded with the discovery ofcell surface receptors on both lysophosphatidic acid (LPA) andsphingosine 1–phosphate (S1P). Since then, thousands of originalresearch reports ranging from fundamental cell signaling tothe physiology and pathophysiology of individual organsystems have centered on lysophospholipids. This book drawstogether and analyzes the current literature to provide readerswith a state–of–the–science review as well as current techniquesthat support research in all aspects of the field oflysophospholipid signaling.


Lysophospholipid Receptors is divided into threesections:



  • Receptors and other possible effectors

  • Enzymes

  • Physiology and pathophysiology


Within each section, the authors explain the similarities anddifferences between LPA and S1P signaling. Examples are providedthat demonstrate the underlying mechanisms of lysophospholipidsignaling across a broad range of organ systems, such as S1Psignaling in cardiovascular physiology and disease and the neuraleffects of LPA signaling. Extensive references at the end of eachchapter provide a gateway to the literature and facilitate furtherresearch into individual topics.


Each chapter has been authored by one or more leadinginternational authorities in lysophospholipid research. Based on athorough analysis of the current research, the authors set forthwhat is established science and offer their expert opinion andperspective on new and emerging areas of research, setting thestage for further investigations that will solve current problemsin the field.


Contents:

PREFACE ix


CONTRIBUTORS xi


1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1
Hope Mirendil, Mu–En Lin, and Jerold Chun


2 SPHINGOSINE 1–PHOSPHATE (S1P) RECEPTORS 41
Bongnam Jung and Timothy Hla


3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID(LPA)–STIMULATED FIBROBLASTS 61
Catelijne Stortelers and Wouter H. Moolenaar


4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE1–PHOSPHATE (S1P) 71
Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel


5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTORTYROSINE KINASE G PROTEIN–COUPLED RECEPTOR SIGNALING COMPLEX85
Nigel J. Pyne and Susan Pyne


6 AUTOTAXIN: A UNIQUE ECTO–TYPE PYROPHOSPHODIESTERASE WITHDIVERSE FUNCTIONS 103
Hiroshi Yukiura and Junken Aoki


7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESISAND EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE ANDELECTROPORATION 121
Masayuki Masu, Seiichi Koike, Takuya Okada, and KazukoKeino–Masu


8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACIDCOMPOUNDS BY NORMAL–PHASE AND REVERSED–PHASECHROMATOGRAPHY TANDEM MASS SPECTROMETRY 137
Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne,H. Alex Brown, and Walter A. Shaw


9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES153
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H.Pham, and Stuart M. Pitson


10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1–PHOSPHATETRANSPORTERS 185
Atsuo Kawahara and Tsuyoshi Nishi


11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BYLYSOPHOSPHOLIPID RECEPTORS 201
Ganesh Venkatraman and David N. Brindley


12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAYMETHODS 229
Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D.Renault


13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULARPATHOLOGY 265
Susan S. Smyth, Anping Dong, Jessica Wheeler, ManikandanPanchatcharam, and Andrew J. Morris


14 SPHINGOSINE 1–PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULARPHYSIOLOGY AND DISEASE 283
Bodo Levkau


15 SPHINGOSINE 1–PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE313
Christian Waeber


16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPAR BYENDOGENOUS LYSOPHOSPHATIDIC ACIDS (LPAS) 349
Ryoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi


17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OFSPHINGOSINE 1–PHOSPHATE (S1P) 373
Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell, and JoanHeller Brown


18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING399
Nobuyuki Fukushima


19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE1–PHOSPHATE (S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THEVERTEBRATE NERVOUS SYSTEM 419
H. Meng and V.M. Lee


20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION ANDLPA BIOSYNTHESIS 433
Hiroshi Ueda


21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES:IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451
Guillermo Estivill–Torrús, Luis Javier Santín, CarmenPedraza, Estela Castilla–Ortega, and Fernando Rodríguez deFonseca


22 SPHINGOSINE 1–PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS475
Alejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab


23 BIOLOGY REVEALED BY SPHINGOSINE 1–PHOSPHATE (S1P) RECEPTORGENE–ALTERED MICE 489
Maria L. Allende, Mari Kono, Aikaterini Alexaki, ChristinaGiannouli, Jiman Kang, Catherine C. Theisen, Eleanor L. Koerner,and Richard L. Proia


24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE507
C. Chris Yun and Peijian He


25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVESYSTEMS 529
Xiaoqin Ye


26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID:PHYSIOLOGICAL AND TOXICOLOGICAL FUNCTIONS OF LYSOPHOSPHATIDIC ACID(LPA) IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 569
Lygia Therese Budnik, Bärbel Brunswig–Spickenheier, andDieter Müller


27 LYSOPHOSPHOLIPID REGULATION OF LUNG FIBROSIS 587
Barry S. Shea and Andrew M. Tager


28 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE 609
Jean Pierre Salles, Sara Laurencin–Dalicieux, FrançoiseConte–Auriol, Fabienne Briand–Mésange, and IsabelleGennero


29 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE CANCER627
Olivier Peyruchaud, Marion David, Timothy L. Macdonald, andKevin R. Lynch


30 UNDERSTANDING THE FUNCTIONS OF LYSOPHOSPHATIDIC ACIDRECEPTORS IN CANCER 641
Nattapon Panupinthu and Gordon B. Mills


31 LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 661
Abir Mukherjee, Jinhua Wu, Yongling Gong, and XianjunFang


32 LPA RECEPTOR SUBTYPES LPA1 AND LPA2 AS POTENTIAL DRUG TARGETS681
Gretchen Bain and T. Jon Seiders


33 CLINICAL INTRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) ANDAUTOTAXIN ASSAYS 709
Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, RyunosukeOhkawa, Akiko Masuda, Akiko Suzuki, Tatsuya Kishimoto, HitoshiIkeda, and Junken Aoki


34 ANTIBODIES TO BIOACTIVE LYSOPHOSPHOLIPIDS 737
Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S.Swaney, and Barbara Visentin


INDEX 753


PRODUCT DETAILS

ISBN-13: 9781118531303
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: May, 2013
Pages: 808

Subcategories: Biochemistry, Diseases and Disorders

MEET THE AUTHOR

JEROLD CHUN, MD, PhD, is a Professor at The Scripps Research Institute in La Jolla, California, and is a pioneer in the field of lysophospholipid signaling.