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Lymphoid Neoplasms 3ed
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Main description:

This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengthened for this third edition, to the environmental factors that may be relevant to disease development, and, finally, to the pragmatic aspects of disease management. The authors synthesise for the reader apsects of current knowledge and likely future developments, and direct them to the appropriate resources should they wish to pursue particular avenues of scientific or literature research.


Contents:

INTRODUCTION
Introduction to the lymphoid neoplasms
Historical perspective: the evolution of modern concepts of lymphoid neoplasia


EPIDEMIOLOGY
Descriptive epidemiology
Causes and prevention of lymphoma
Immunologic and genetic predisposition
Epidemiology of exogenous human retroviruses associated with hematologic malignancies
Herpesviruses and lymphoma
Other microorganisms associated with lymphoid neoplasms


IMMUNOBIOLOGY
Overview of the immune system
Ontogeny of T and natural killer cells
Ontogeny of B cells
Cellular immunobiology of lymph nodes and spleen
Cellular immunobiology of extranodal lymphoid tissue
Biology of plasma cells
Interleukins and lymphoid neoplasia
Lymphocyte homing and the dissemination of lymphoid malignancies
Mouse models of human B lymphoid neoplasms


CLASSIFICATION AND PATHOGENESIS
Classification of lymphoid neoplasms
Borderlands between pathological entities: composite lymphomas
Chromosomal and molecular alterations in lymphoid malignancies: basic principles and detection methods
Molecular basis of chromosomal translocations
Genesis and consequences of genetic lesions in lymphoma classification
Gene expression patterns in lymphoma classification
Immunodeficieny, inherited and acquired, and lymphomagenesis
Chronic inflammation, including autoimmunity, and lymphogenesis


PATHOLOGY AND PATHOGENESIS OF SPECIFIC LYMPHOMAS
Lymphoblastic lymphomas and leukemias
Chronic lymphoid leukemias and u heavy chain disease
Hairy cell leukemia
Mantle cell lymphoma
Marginal zone lymphomas
Follicular lymphoma
Burkitt lymphoma
Diffuse large B cell lymphomas
Hodgkin lymphoma
Plasma cell neoplasms
Natural killer (NK) cell neoplasms
Anaplastic large cell lymphoma
Mycosis fungoides and Sezary Syndrome: pathophysiology and pathology
Other peripheral T cell lymphomas: pathology and molecular pathogenesis


PRESENTING FEATURES, DIAGNOSIS AND STAGING
Presenting features of lymphoid neoplasms
The art of histological diagnosis
Immunophenotyping as a diagnostic and prognostic tool
The utility of molecular genetic studies in the diagnosis, prognostic assessment and monitoring of lymphoid malignancies
Radiologic, ultrasound and magnetic resonance imaging
Radionuclide imaging
Staging systems and staging investigations at presentation
Special aspects of diagnosis in developing countries
Imaging lymphomas in developing countries


GENERAL PRINCIPLES OF MANAGEMENT
Emergency management in lymphoid malignancies
Systemic therapy of lymphoma
Role of radiation therapy
Response assessment and follow-up of the patient with malignant lymphoma
Prognostic factors and risk adaptation
Second-line therapy for lymphoid neoplasms
High-dose therapy with stem cell rescue
Management of lymphoid neoplasia during pregnancy
Management of lymphoid malignancies in the infant
Management of lymphoid neoplasms in the elderly
Management of lymphomas at extranodal locations
Special aspects of management of lymphomas in developing countries
Late effects of cancer treatment and quality of life


MANAGEMENT OF SPECIFIC DISEASES
Lymphoblastic lymphoma and leukemia in children
Acute lymphoblastic leukemia and lymphoma in adults
Small B cell lymphomas and leukemias with hairy cell leukemia
Mantle cell lymphoma
Marginal zone lymphomas
Follicular lymphoma
Burkitt lymphoma/leukemia in children
Burkitt and Burkitt like lymphoma/leukemia in adults
Diffuse large B cell lymphoma in children
Diffuse large B cell lymphomas in adults
Hodgkin lymphoma in adults
Hodgkin lymphoma in children
Plasma cell neoplasms
The management of natural killer cell malignancies
Anaplastic large cell lymphoma in adults
Anaplastic large cell lymphoma in children
Mycosis fungoides and Sezary Syndrome
Adult T-cell leukemia/lymphoma
Other peripheral T cell lymphomas
HIV-associated lymphoid neoplasms
Lymphoid neoplasms in immunodeficiency, immunosuppression, and autoimmunity
Uncommon histologic subtypes of non-Hodgkin lymphoma in children


FUTURE DIRECTIONS IN DIAGNOSIS AND TREATMENT
Molecular profiling and lymphoma diagnosis
New therapies for lymphoid neoplasms
Monoclonal antibody therapy for lymphomas and leukemias
Cellular therapies for lymphoma
Vaccine therapies
Lymphoma microenvironment
Molecular pathway therapy for non-Hodgkin lymphomas
Therapeutic strategies employing viral-associated targets


PRODUCT DETAILS

ISBN-13: 9781444113228
Publisher: Taylor & Francis (CRC Press)
Publication date: July, 2010
Pages: 1689

Subcategories:

MEET THE AUTHOR

Ian T. Magrath DSc (Med), FRCP, FRCPath
President, International Network for Cancer Treatment and Research,
Adjunct Professor of Pediatrics, Uniformed Services University of the Health Sciences,
International Network for Cancer Treatment and Research,
Brussels, Belgium

Section editors:

Kishor Bhatia PhD, FRCPath
Director, AIDS Malignancy Program
OHAM, NCI, NIH
Bethesda, MD
USA

Paolo Boffetta MD, MPH
Head of Environment Section, IARC
Lifestyle and Cancer Group
International Agency for Research on Cancer
Lyon
France

Claire Dearden BSc, MD, FRCP, FRCPath
Consultant Haematologist
Department of Haemato-Oncology
Royal Marsden NHS Foundation Trust and Institute of Cancer Research
London
UK

Volker Diehl MD, PhD
Professor of Internal Medicine, Hematology and Oncology
Honorary Chairman of German Hodgkin Study Group (GHSG)
Former Head of Department I of Internal Medicine
University Hospital Cologne
Cologne
Germany

Randy D. Gascoyne MD, FRCPC
Clinical Professor of Pathology
Department of Pathology and Laboratory Medicine
British Columbia Cancer Agency and
The University of British Columbia
Research Director, Centre for Lymphoid Cancers
Senior Scientist, BC Cancer Research Centre
Vancouver, BC
Canada

Hans Konrad Müller-Hermelink Prof. Dr. Dr. h. c.
Professor and Chairman
Institute of Pathology
University of Würzburg
Würzburg
Germany

Michael Potter MD
Scientist, Emeritus
Laboratory of Cell Biology and Genetics
National Cancer Institute, NIH
Bethesda, MD
USA

Ama Z. S. Rohatiner MD, FRCP
Professor of Haemato-Oncology
Department of Medical Oncology,
St. Bartholomew's Hospital
London
UK