Increasing use of ketamine as a recreational drug in Asia, Europe, and America is a great burden on society at large, leading to aspirational strain, unemployment, and crime. These societal effects have led to growing interest among researchers and clinicians in ketamine's effects on various systems of the body. Ketamine: Use and Abuse reviews the acute and chronic effects of ketamine on both adult and developing animals and humans. Providing an exhaustive review of the literature, the book is supplemented by the introduction of new data and research.
Topics include: * The pharmacological properties of ketamine * The impact of ketamine on various organ systems, including the central nervous system and the gastrointestinal, respiratory, adrenal, and renal systems * Developmental neurotoxicity in the developing brain * Postmortem toxicology * The epidemiology of misuse and patterns of acute and chronic toxicity * The psychosocial aspects of ketamine addiction * Clinical applications at acceptable doses, including possible contribution to the treatment of depression The contributions in this book represent an initiative to investigate the different facets of ketamine beyond the known psychosocial factors related to addiction and its traditional use as an anesthetic agent. The broad-based coverage is designed to promote heightened attention on the subject and encourage further research into beneficial clinical uses.
Ketamine use and misuse-Impacts on the nervous system: An overview David T.W. Yew Clinical applications and side effects of ketamine Ou Sha, Yue Hao, Eric Yu-Pang Cho, and Li Zhou Diverse pharmacological properties of ketamine Ismail Laher, Xin Zhang, Ping Chung Leung, and Willmann Liang Developmental neurotoxicity of ketamine in the developing brain Chaoxuan Dong Ketamine-Epidemiology of misuse and patterns of acute and chronic toxicity Shwetha S. Rao, David M. Wood, and Paul I. Dargan Imaging the effects of ketamine use and abuse in the brain Qi Li, Sherry K.W. Chan, Lin Sun, Wai-Chi Chan, Eric Y.H. Chen, and Pak C. Sham Does sniffing drugs affect the respiratory system? An example being ketamine Maria S.M. Wai, Jacqueline C. Lam, Lawrence K. Hui, and David T.W. Yew Long-term ketamine use causes damage to the pancreas and adrenal glands Wai Ping Lam, Tan Sijie, Lok Hang Lam, Yeak Wan Wong, and Chun-Mei Wang Ketamine uropathy: Hong Kong experience Peggy Sau Kwan Chu, Chi Fai Ng, and Wai Kit Ma Ketamine and the lower urinary tract: Summary of pathophysiological evidence in humans and animal models Hong Chai Tang, Phoebe Y.H. Lam, and Willmann Liang Postmortem toxicology of ketamine James Watterson The antidepressant effects of ketamine and the underlying mechanisms Nan Wang and Jian-Jun Yang Social correlates of ketamine and other psychoactive drug abuse in Hong Kong Yuet-Wah Cheung Mechanisms of ketamine-induced neuroplasticity: Potential effects on brain and behavior Vincenzo Tedesco, Ginetta Collo, and Cristiano Chiamulera The influence of ketamine on our understanding of depression Andrew M. Perez Clinical testing for ketamine: How it inspires the need to develop emerging drugs-of-abuse analysis in a clinical laboratory Magdalene H.Y. Tang, Calvin Y.K. Chong, Doris C.K. Ching, and Tony W.L. Mak