eBOOKS BY CATEGORY
Your Account
Insertional Mutagenesis Strategies in Cancer Genetics
Price
Quantity
£108.75
(To see other currencies, click on price)
PDF
Add to basket  

MORE ABOUT THIS BOOK

Main description:

The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.


Feature:

This work summarizes the contribution that insertional mutagenesis has made to our understanding of cancer

A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms

The impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials


Back cover:

Over the past decades, insertional mutagenesis has played an important contribution to our understanding of cancer. Initially, the action of slow transforming retroviruses was used to identify endogenous cellular oncogenes (e.g. Myc, Myb). These observations sparked a series of experiments that eventually led to the idea cancer is caused by somatically acquired mutations in endogenous oncogenes and tumor suppressor genes.
Since these discoveries, insertional mutagenesis has been used to identify novel cancer genes in a variety of tumor types in animal models of cancer. More recent work has developed novel insertional mutagens, such as transposons, that have broader capabilities to model cancer in vivo. While this work has focused on developing animal models of cancer, recent gene therapy trials in human patients have shown that insertional mutagenesis can also contribute to transformation.
The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.


Contents:

Chapter 1: Introduction
Author: Anton Berns (Netherlands Cancer Institute)

Chapter 2: Retroviral mutagenesis in mouse leukemia/lymphoma
Author: David Largaespada, Ph.D. (University of Minnesota)

Chapter 3: MMTV models of breast cancer
Author: John Hilkens (NKI)

Chapter 4: Retroviral mutagenesis in other organisms
Author: Michael Dvorak (Inst. Of Molecular Genetics, Prague, Czech Rep.)

Chapter 5: Sleeping Beauty models of cancer
Author: Adam J. Dupuy, Ph.D. (University of Iowa)

Chapter 6: Insertional mutagenesis in gene therapy patients
Author: David Williams, M.D. (Cincinnati Children’s Hospital)

Chapter 7: Bioinformatics of high throughput insertional mutagenesis
Author: Keiko Akagi (NCI-Frederick)


PRODUCT DETAILS

ISBN-13: 9781441976567
Publisher: Springer (Springer New York)
Publication date: November, 2010
Pages: 208

Subcategories: Genetics, Oncology, Pharmacology

MEET THE AUTHOR

Adam Dupuy, Ph.D., is an Assistant Professor at the Carver College of Medicine at the University of Iowa, and a rising star in the field of insertional mutagenesis; two of the last of his publications have been in Nature, and he was the lead author on one of these. Dr. Dupuy earned his B.A. at Central College in Pella, Iowar, went on to earn his Ph.D. at the University of Minnesota in the Program in Molecular, Cellular, Developmental Biology & Genetics, and did his Postdoctoral fellowship in the Mouse Cancer Genetics Program at the NCI-Frederick.