The book elucidates the role of inorganic polyphosphates in eukaryotic cells, from fungi and protozoa to human being. To date, there is plenty of evidence that these anionic biopolymers occurring in the cells of all living organisms, from bacteria to humans, perform numerous regulatory functions. The book describes the evolution of PolyPs, their role in lower eukaryotes and their involvement in various processes in the human organism, as well as its use in biomaterials such as bioactive glass and engineered bone tissue. The aim of this book is to summarize the data of the past decade on the functional role of inorganic polyphosphates in eukaryotes and discuss their biological role also in context of common human diseases. The book will provide a modern concept of the functional significance of these biopolymers, useful for researchers in cell biology, biochemistry, molecular biology and biomedicine alike.
Inorganic polyphosphate multiple function in eukaryotic cell and prospects of these polymers in industry, agriculture and medicine.- The role of inorganic polyphosphate in the stress response and enzyme activities regulation in yeast.- Inorganic polyphosphate in acidocalcisome of protozoa and its role in pathogenesis.- Inorganic polyphosphate in algae.- Inorganic polyphosphates in mycorrhiza.- Inositol polyphosphate and inorganic polyphosphate in cellular functions and human diseases.- PolyP-Ca-polyhydroxybutyrate channels structure and role in eukaryotes.- Inorganic polyphosphates in mitochondria.- Inorganic polyphosphates in brain.- Inorganic polyphosphate in dental tissue development and regeneration.- Inorganic polyphosphate as an inducer of alkaline phosphatase and a modulator of intracellular Ca(2+) level in osteoblasts.- Inorganic polyphosphate and biological apatite nucleation.- Inorganic polyphosphate in blood coagulation.- Inorganic polyphosphate in inflammation.- Prune protein, cancer, Inorganic polyphosphate.- Conclusion: Evolution of the polyphosphate role in eukaryotes.