This book presents the full range of management techniques and practices used in induction chemotherapy - both systemic and locoregional - by experienced international groups within one accessible volume. It provides the latest information on the pioneering and cutting-edge practices employed in different institutions and documents the advantages of integrated treatment schedules. All those responsible for treating patients with locally advanced cancers may find new, interesting aspects of locoregional cancer management and will find this book to be an invaluable source of up-to-date information. Throughout the world, induction chemotherapy is being used as part of an integrated plan of management for locally advanced, solid tumors, while systemic chemotherapy is most commonly used to shrink primarily non-operable tumors. In cases of poorly or nonresponsive tumors, attempts have been made to administer chemotherapeutics via the arterial route in order to achieve higher localized drug exposure and response rates. Such therapies are being practiced worldwide in independent, remote departments in universities, teaching hospitals and clinical schools.
Frequently, however, these teams remain relatively unaware of the work being done in other institutions, which may slow further progress.
Introduction: Overview, History, Terminology and Early Clinical Experience.- The Principle of Dose-Response in Antineoplastic Drug Delivery.- Drug Removal Systems and Induction Chemotherapy.- Cryotherapy.- Local and Regional Hyperthermia.- The Role of Hypoxia and Hyperthermia in Chemotherapy.- Induction Chemotherapy in Head and Neck Cancers.- Isolated Thoracic Perfusion with Carotid Artery Infusion for Advanced and Chemoresistant Tumors of the Parotid Gland.- Induction Chemotherapy For Breast Cancer.- Patients with Locally Advanced Breast Cancer receiving Intra-Arterial Induction Chemotherapy: report of a Phase II Clinical Study.- Regional Chemotherapy with Thoracic Wall Recurrence and Metastasized Breast Cancer.- Cytoreductive Surgery and "Hyperthermic Intraperitoneal Chemotherapy-HIPEC.- Induction Bidirectional Chemotherapy for Gastric Cancer with Peritoneal Dissemination.- Esophageal Cancer.- Gastric Cancer.- Systemic and Regional Chemotherapy for Advanced and Metastasized Pancreatic Cancer.- Interventional Radiological Procedures for Port-Catheter Implantation.- Induction chemotherapy for hepatocellular carcinoma.- Transarterial Treatment of Primary and Secondary Liver Tumors.- Pelvic Perfusion for Rectal Cancer.- Isolated Pelvic Perfusion with Chemofiltration for Pelvic Malignancies - Anal, Cervical and Bladder Cancer.- Penile cancer treated by intra-arterial infusion chemotherapy.- Systemic Induction Chemotherapy for Advanced Stage Epithelial Ovarian Cancer.- Regional Chemotherapy in Recurrent Platinum-Refractory Ovarian Cancer.- Isolated Limb Perfusion for Melanoma.- Isolated Limb Infusion.- Induction treatment in sarcomas.- Isolated Limb Perfusion for Locally Advanced Soft Tissue Sarcoma.- Induction Chemotherapy in Treatment of Sarcomas.- Isolation Perfusion Systems: Lungs.- Metastatic Cancers in Lung: Isolated Lung Perfusion - Clinical Studies.- Isolated Thoracic Perfusion with Chemofiltration (ITP-F) for Advanced and Pre-treated Non-Small-Cell Lung Cancer.- Toxicity Profiles with Systemic versus Regional Chemotherapy.