Since publication of the First Edition, advances in the diagnosis and prevention and treatment strategies of the vulnerable plaque have necessitated this greatly expanded second edition. With several new chapters covering mainly diagnostic and treatment options, The Handbook of the Vulnerable Plaque will remain the benchmark text for all interventional cardiologists treating vulnerable patients by providing the physician with comprehensive insight into the world of the vulnerable plaque.
Definition and Terminology of the Vulnerable Plaque. Pathology of the Vulnerable Plaque. Molecular Basics of Vulnerable Plaque. Genetics of the Vulnerable Plaque. Platelets and Vulnerable Plaque. Macrophages: Good, Bad or Ugly?. Metalloproteinase. VP: An Immunology Disease. Oxidative Stress and Vulnerability. Carotid VP. Diabetes Mellitus and VP. Psychological Triggers for Plaque Rupture. Animal Models. The Endothelial Markers. Biomarkers. Epidemiology of LpPLA2. Inhibition of LpPLA2. Angiography. Imaging the Vulnerable Plaque by Ultrasound. Palpography. Infrared Spectroscopy. Virtual Histology. Functional Measurement for Vulnerable Plaque Detection. Vulnerable Plaque and Shear Stress. Vasa Vasorum and Vulnerable Plaques. Intravascular MRI. Thermography: Basic Principles. Thermography: Clinical Aspects. Targeted Contrast. Nuclear Imaging of Vulnerable Plaques. Nanoparticels. MSCT. MRI. Vaccination: Bench. Vaccination: Bedside. Immunisation. Statins. Beyond Statins, Pharmaceutical Therapies for the Vulnerable Plaque. Stem Cell Therapy. Phototherapy. Stents for VP Treatment. Clinical Perspective of the Vulnerable Plaque. New Mechanisms for the Vulnerable Plaque. Prospect. IBIS. Prevail. Regulatory Issues of the FDA. Economics / Reimbursement. The Investors View