This handbook covers the entire field of magnetic resonance spectroscopy (MRS), a unique method that allows the non-invasive identification, quantification and spatial mapping of metabolites in living organisms including animal models and patients. Comprised of three parts: * Methodology covers basic MRS theory, methodology for acquiring, quantifying spectra, and spatially localizing spectra, and equipment essentials, as well as vital ancillary issues such as motion suppression and physiological monitoring. * Applications focuses on MRS applications, both in animal models of disease and in human studies of normal physiology and disease, including cancer, neurological disease, cardiac and muscle metabolism, and obesity. * Reference includes useful appendices and look up tables of relative MRS signal-to-noise ratios, typical tissue concentrations, structures of common metabolites, and useful formulae. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine.
The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit the eMagRes Homepage
1 Basics of NMR 2 Magnetic Resonance Spectroscopy Instrumentation 3 Detection coils for MRS 4 A Practical Guide to in-vivo MRS 5 Adiabatic Excitation Pulses for MRS 6 Localized MRS employing radiofrequency field (B1) gradients 7 Single Voxel MRS 8 Chemical shift imaging with phase- and sensitivity-encoding 9 Spatial Encoding and Decoding with Prior Knowledge from MRI and Spatio-Spectral Correlation 10 Accurate Localized Spectroscopy from Anatomically Matched Regions with Optimal Spatial Response Function 11 Accelerated Spatially-Encoded MRS of Arbitrarily-Shaped Compartments Using Linear Algebraic Modeling 12 High-Speed Spatial-Spectral Encoding with Echo-Planar and Spiral Spectroscopic Imaging 13 Direct Water--Fat Imaging Methods: Chemical Shift-Selective and Chemical Shift-Encoded MRI 14 Physiological maintenance in animal experiments 15 Physiological maintenance in MRI and MRS of large animals 16 Physiological Monitoring in human MRS 17 Physiologic Motion: Dealing with Cardiac, Respiratory and Other Sporadic Motion in MRS 18 Quantifying Spectra in the Frequency Domain 19 Quantifying Spectra in the Time Domain 20 Advanced spectral quantification: parameter handling, non-parametric pattern modeling and multi-dimensional fitting 21 1H-NMR Chemical Shifts and Coupling Constants for Brain Metabolites 22 Pattern Recognition Analysis of MR Spectra 23 Quantifying Metabolite Ratios and Concentrations by 1H MRS 24 Quantifying Metabolite Ratios and Concentrations by Non-1H MRS 25 Measuring intra- and extra-cellular pH by MRS 26 Temperature Monitoring Using Chemical Shift 27 Diffusion-Weighted MRS 28 Measuring biochemical reaction rates in vivo with magnetization transfer 29 Proton Chemical Exchange Saturation Transfer MRS and MRI 30 Two-Dimensional NMR Spectroscopy Plus Spatial Encoding 31 Spectral editing 32 Multiple quantum MRS 33 Hyperpolarization Methods for MRS 34 Pulse sequences for hyperpolarized MRS 35 MRS of Perfused Cells, Tissues and Organs 36 Metabolism and Metabolomics by MRS 37 In Vivo 19F MRS 38 13C MRS in Human Tissue 39 Hyperpolarized 13C MRI and MRS Studies 40 Integrating 13C Isotopomer Methods with Hyperpolarization for a Comprehensive Picture of Metabolism 41 Muscle studies by 1H MRS 42 Muscle Studies by 31P MRS 43 Measuring Intracellular Oxygenation with Myoglobin 1H MRS 44 Body Fat MRS 45 In Vivo MRS of Lipids in Adipose Tissue, Bone Marrow, and Liver 46 Assessing Fatty Liver with MRS 47 MRS Studies of Muscle and Heart in Obesity and Diabetes 48 Studying Cardiac Lipids in Obese and Diabetic patients by 1H MRS 49 Cardiac MRS Studies in Rodents and Other Animals 50 Assessing Cardiac Transplant Viability with MRS 51 MRS in the Failing Heart: from Mice to Humans 52 MRS studies of Creatine Kinase metabolism in human heart 53 Studying Aging, Dementia, Trauma, Infection, and Developmental Disorders of the Brain with 1H MRS 54 Studying Stroke and Cerebral Ischemia by 1H MRS 55 31P MRS in Psychiatric Disorders 56 The significance of N-Acetyl Aspartate in Human Brain MRS 57 MRS in Brain Cancer 58 MRS in Breast Cancer 59 MRS in Prostate Cancer 60 Clinical Trials of MRS Methods 61 Clinical Trials that Utilize MRS as a Biomarker 62 Properties of NMR-visible isotopes and their biological content in human tissue 63 Concentration ranges of common metabolites detected by MRS in healthy human tissue 64 Peak Assignments for Some Common Metabolites 65 Biochemical reactions and molecular structures of common MRS metabolites 66 Some standard formulae used in MRS 67 Common MRS Artefacts 68 In Vivo Spectra with Peak Assignments