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Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, Second Edition
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Main description:

Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility-related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs-regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.


Contents:

INTRODUCTION

Biomaterials and Manufacturing Methods for Scaffolds in Regenerative Medicine: Update 2015

Introduction
Biomaterials for Regenerative Medicine and Tissue Engineering
Scaffold Fabrication and Characterization
Concluding Remarks and Future Directions
References

CERAMIC AND METAL SCAFFOLDS

Biomineralized Matrices as Intelligent Scaffolds for Bone Tissue Regeneration

Introduction
CaP Biomaterials
CaP-Based Biomaterial-Assisted Osteogenic Differentiation of Stem Cells
CaP Matrices for Bone Tissue Engineering and Repair
CaP Mineral-Based Matrices as a Delivery Vehicle for Growth Factors and Genes
CaP-Assisted Stem Cell Osteogenesis and Bone Tissue Regeneration: Mechanistic Insights
Conclusions and Future Perspectives
References

Bioceramic and Composite Scaffolds in Drug Delivery and Bone Tissue Engineering

Introduction
Bioceramics
Nanotechnology in Bioceramics
Nanoceramics in Drug Delivery
Bone Tissue Engineering
Research Perspective
Basic Questions in Bone Tissue Engineering
Conclusions
References

Recent Development in Materials Innovation in Bone Tissue Regeneration

Overview
Materials' Innovation
Microstructure and Morphology Optimization of Bioceramic-Based Bone Substitutes
Current Challenges and Future Directions in Bone Substitute Research
Conclusions
References

Carbonate Apatite Scaffolds for Regenerative Medicine

Introduction
Fabrication of Carbonate Apatite by Compositional Transformation Based on Dissolution-Precipitation Reaction Using a Precursor
Cell and Tissue Response to Carbonate Apatite
Porous Carbonate Apatite
Conclusions
References

Mg-Based Biodegradable Metals for Scaffolds

Introduction
Mg-Based Biodegradable Metals for Bone Scaffolds
Mg-Based Biodegradable Metals for Blood Vessel Scaffolds/Stents
Concluding Remarks
References

INTELLIGENT HYDROGELS

Functional DNA Building Blocks and Their Hydrogel Scaffolds for Biomedical Applications

Overview
DNA Nanobuilding Blocks
DNA Hydrogels
Functionalized DNA Hydrogels
Protein-Producing DNA Hydrogels
Conclusions
References

Recent Progress of Intelligent Hydrogels for Tissue Engineering

Introduction
History of Hydrogels
Properties of Hydrogel Scaffolds for Successful Tissue Engineering
Classification of Hydrogels
Conclusions
References

Polyanionic Hydrogels as Biomaterials for Tissue Engineering

Overview
Properties of Polyanionic Hydrogels
Polyanionic Hydrogels for Replacement of Biotissues
Polyanionic Hydrogels for Tissue Regeneration
Conclusions
References

Hyaluronic Acid-Based Hydrogel as a Scaffold for Tissue Engineering

Introduction
Characteristics of Hyaluronic Acid in Tissue Engineering
HA Derivatives
Fabrication of Hyaluronic Acid Hydrogels
Hyaluronic Acid-Based Hybrid Hydrogels
Conclusions and Outlook
References

Biologically Triggered Injectable Hydrogels as Intelligent Scaffolds

Introduction
Injectable Hydrogels as a Regenerative Scaffold
Enzyme-Triggered Hydrogels
Conclusions and Outlook
References

Cytocompatible and Reverse-Transformable Polymeric Hydrogel Matrices

Introduction
Polymer Hydrogel as an Artificial ECM
Physically Forming Crosslinkable Hydrogels
Stimuli-Responsive Hydrogels
Reversible and Spontaneously Forming Hydrogels
Rheological Properties of PMBV/PVA Hydrogels
Control of Cell Proliferation through PMBV/PVA Hydrogels
Differentiation Induction of Stem Cells Encapsulated in the PMBV/PVA Hydrogels
Conclusions and Future Perspectives
References

"Smart" Hydrogels in Tissue Engineering and Regenerative Medicine Applications

Introduction
Stimuli-Responsive Hydrogels: Types, Properties, and Applications
Processing of Hydrogels
Final Remarks and Future Trends
References

Cell-Encapsulating Polymeric Microgels for Tissue Repair

Introduction
Natural and Synthetic Polymers for Cell-Encapsulating Microgels
Fabrication Methods of Microgels for Cell Encapsulation
Design Considerations of Microgels for Cell Encapsulation
The Application of Cell-Encapsulating Microgels for Tissue Repair
Challenges for Clinical Translation
Summary and Future Perspectives
References

Injection Materials for the Larynx

Overview
Anatomy of the Vocal Fold
Pathologic Changes of the Vocal Fold in Glottal Insufficiency
General Principles of Injection Laryngoplasty for Vocal Fold Paralysis
General Characteristics of the Materials Currently Available for Vocal Fold Augmentation
Ideal Materials for Injection Laryngoplasty
Summary
References

Bionanocrystals in Tissue Engineering Strategies: Tools for Reinforcement, Nanopatterning, and/or Nanostructuring of Polymeric Scaffolds and Hydrogels

Introduction
Potential of PNCs in Tissue Engineering Strategies
Nanopatterned Surfaces
Nanostructured Films and Coatings
Porous Foam and Sponge Scaffolds
Fibrous Nanocomposities
Hydrogel Nanocomposites
Concluding Remarks
References

ELECTROSPINNING SCAFFOLDS

Porous Scaffolds Using Dual Electrospinning for in situ Cardiovascular Tissue Engineering

Introduction: Cardiovascular Tissue Engineering
Electrospinning
Cell Infiltration into Electrospun Scaffolds
Scaffold (An)isotropy
Controlling Scaffold Porosity
Mechanical Properties and Degradation Rate
Conclusions
References

Biofunctionalization of Electrospun Fibers for Tissue Engineering and Regenerative Medicine

Introduction
Electrospinning Process
Functionalization of Electrospun Fibers
Applications
Conclusions
References

Electrospun Fibrous Scaffolds

Introduction
Electrospinning Process
Advanced Fabrication Methods
Applications for Tissue Engineering
References

3D PRINTING FOR SCAFFOLDS

3D Printing of Tissue/Organ Scaffolds for Regenerative Medicine

Overview
The Modeling of Tissue/Organ Scaffolds
Material Selection
Technique Limitations
Conclusions and Prospects
References

3D Printing Technology Applied to Tissue Scaffolds

Introduction
3D Printing Methods Applied to Scaffolds
Summary
References

NANO-/BIOCONVERGENCE TECHNOLOGY FOR SCAFFOLDS

Nanomaterial-Assisted Tissue Engineering and Regenerative Medical Therapy

Introduction
Potential Risk of Nanomaterials
Conclusions and Future Perspectives
References

Application of Nanodevices in Sensing and Regenerative Medicine

Introduction
Fabrication of Nanodevices
Applications of Nanodevices
Conclusions
References

Micro-/Nanotech-Based Craniofacial Tissue Engineering

Overview
Micro-/Nanotech-Based Craniofacial Tissue Engineering
Conclusions
References

Carbon Nanotubes: A Kind of Novel Biomaterials for Scaffolds of Tissue Engineering

Introduction
Carbon Nanotubes in Bone Tissue Engineering
Nerve Tissue Engineering
The Others
References

ACELLULAR NATURAL MATRICES FOR SCAFFOLDS

Bacteriophage Scaffolds for Functional Assembly of Molecules and Nanomaterials

Overview
Phage Display
Phage Platform for Biological Applications
Genetic Modification of Phages to Create Inorganic Structures
Phage Display with Extended Genetic Codes
Conclusions
References

Intelligent Scaffold-Mediated Enhancement of the Viability and Functionality of Transplanted Pancreatic Islets to Cure Diabetes Mellitus

Overview
Scaffolds Fabricated with ECM Molecules Decellularized from the Pancreas
Natural Polymer-Based Scaffolds
Synthetic Polymer-Based Scaffold
Natural and Synthetic Polymer Composite-Based Scaffold
Conclusions
References

Extracellular Matrix-Derived Biomaterials: Molecularly Defined Ingredients and Processing Techniques

Introduction
Extracellular Matrix
Molecularly Defined Biomaterials
Techniques and Major Tools for Scaffolding
Summary and Future Perspectives
References

Biological-Derived Biomaterials for Stem Cell Culture and Differentiation

Introduction
Stem Cell Engineering
Biological-Derived Materials
Summary and Future Direction
References

Demineralized Dentin Matrix (DDM) Scaffolds for Alveolar Bone Engineering

History of the Demineralized Dentin Matrix
Characteristics of Scaffolds for Alveolar Bone Repair
Development of DDM Scaffolds
DDM Scaffolds with Recombinant Human BMP-2
Clinical Applications
Tooth Banks: Present and Future
References

Biomimetic Scaffold Fabrication for Tissue Engineering

Introduction
Biomimetic 2D Substrate Fabrication
Biomimetic 2D Substrate Modification
Biomimetic Surface Modification Methods
3D Scaffold Fabrication
Biomimetic Modification of 3D Scaffolds
Future Direction
Conclusions
References

SCAFFOLDS FOR TARGET ORGANS

Scaffolds for Tracheal Regeneration

Structure and Function of the Trachea
Tissue Engineering for Tracheal Stenosis
Scaffolds for Tracheal Regeneration
Cells
Bioreactors
Summary
References

Bladder Tissue Engineering

The Urinary Bladder: Function and Structure
Bladder Reconstruction and Augmentation
Materials for Bladder Tissue Engineering
Cell Seeding
Vascularization
Stem Cells in Bladder Tissue Engineering
Animal Studies and Clinical Trials
Future Perspectives: A Complete Bladder?

Scaffold Applications for Vascular Tissue Engineering

Introduction
Synthetic Biodegradable Polymer Scaffolds
Collagen and Other Biopolymer Scaffolds
Decellularized Tissue Scaffolds
Cell-Based Vascular Tissue Engineering
In situ "Cell Free" Vascular Tissue Engineering
Conclusions
References

Annulus Fibrosus Tissue Engineering: Achievements and Future Development

Introduction
Fundamentals of Annulus Fibrosus
Cells for Annulus Fibrosus Tissue Engineering
Scaffolds for Annulus Fibrosus Tissue Engineering
Growth Stimuli for Annulus Fibrosus Tissue Engineering
Concluding Remarks
References

Corneal Endothelium Regeneration: Basic Concepts

Introduction
Corneal Endothelium
Bioengineered Corneal Endothelium
Conclusions
References

DRUG DELIVERY SYSTEM FOR SCAFFOLDS

High-Throughput Screening of Extracellular Matrix-Based Biomaterials

Basic Principles
Relation to Materiomics
Future Perspectives
Classical Experiment 1: Biomaterial Array
Classical Experiment 2: Gene Expression Microarrays
References

Effect of Scaffolds with Bone Growth Factors on New Bone Formation

Introduction
Bone Lengthening in Preclinical Animal Studies
Growth Factor-/Stem Cell-Mediated Scaffolds for Bone Tissue Engineering
The Use of Scaffolds with or without Growth Factors and Cells for Clinical Trials
References

Drugs as Novel Biomaterials for Scaffolds

Overview
Drug Repositioning
Background and Structure of Fragmin and Protamine
Implications of Drug Repositioning in Tissue Engineering and Regenerative Medicine
Conclusions
References

FUTURE ENABLING TECHNOLOGY FOR SCAFFOLDS

Biocompatible Surface Coatings for Silicone-Based Implants

Overview
Surface Oxidation of Silicone Implants
Surface Coating with Bio-originated Materials
Surface Coating with Artificial Materials
Conclusions
References

Synthetic/PLGA Hybrid Scaffold for Tissue Regeneration: Update 2015

Introduction
Biomaterials for TERM
Hybrid and Composite Scaffold Biomaterials for TERM
PLGA/Natural Hybrid Scaffolds in Our Laboratory
Conclusions
References

Biomedical Applications of Silk Fibroin

Overview
Silk Fibroin Processing
Tissue Engineering Application of Silk Fibroin-Based Biomaterial
Conclusions
References

Tissue Fabrication and Regeneration by Cell Sheet Technology

Overview
Temperature-Responsive Culture Surface and Cell Sheets
Fabrication and Regeneration of 3D Tissues Using Cell Sheet Technology
Automation and Mechanization for Fabrication of 3D Tissues
Conclusions
References

Stem Cell Engineering Using Bioactive Molecules for Bone-Regenerative Medicine

Overview
First-Generation Bioactive Molecules: Proteins
Bioactive Molecules: Peptides
Bioactive Molecules: Small Molecules
Conclusions and Outlook
References


PRODUCT DETAILS

ISBN-13: 9789814745130
Publisher: Pan Stanford Publishing Pte Ltd
Publication date: May, 2017
Pages: 1480

Subcategories: Biomedical Engineering, General Issues