Flavonoids exert a multiplicity of biological effects on humans and can have beneficial implications for numerous disease states. Flavonoids and Related Compounds: Bioavailability and Function examines current knowledge regarding the absorption, metabolism, and bioavailability of individual flavonoids and related phenolic compounds. Profiling the latest evidence of their impact on various human pathological conditions, the book summarizes current thinking with regard to the biotransformation and conjugation of individual compounds in the gastrointestinal tract, liver, large intestine, and cells. It highlights a topic that has been largely ignored-namely the extent to which dietary phenolics components undergo metabolism in the large intestine. It also explores the generation of bacterially derived metabolites. Individual chapters discuss which metabolites enter the circulatory system and are likely to offer protective actions against human diseases.
Edited by internationally recognized leaders in the field, the book presents contributions by a panel of experts who demonstrate the potential of flavonoids in ameliorating a range of disease states, including cardiovascular disease, Alzheimer,s and Parkinson,s disease and other neurodegenerative disorders, and cancer. The research presented in this volume provides a reliable starting point for further inquiry and experimentation.
Bioavailability of Flavanones; M. Urpi-Sarda, J. Rothwell, C. Morand, and C. Manach Bioavailability of Dietary Monomeric and Polymeric Flavan-3-ols; A. Crozier, M. N. Clifford, and D. Del Rio Anthocyanins: Understanding Their Absorption and Metabolism; R. L. Prior Bioavailability of Flavonols and Flavones; M. K. Piskula, K. Murota, and J. Terao Bioavailability of Isoflavones in Humans; A. Cassidy, J. Penalvo, and P. Hollman Dietary Hydroxycinnamates and Their Bioavailability; A. Stalmach, G. Williamson, and M. Clifford Bioavailability of Dihydrochalcones; E. Richling Occurrence, Bioavailability, and Metabolism of Resveratrol; P. Vitaglione, S. Sforza, and D. Del Rio Bioavailability and Metabolism of Ellagic Acid and Ellagitannins; M. Larrosa, M. T. Garcia-Conesa, J. C. Espin, and F. A. Tomas-Barberan Colon-Derived Microbial Metabolites of Dietary Phenolic Compounds; A.-M. Aura Synthesis of Dietary Phenolic Metabolites and Isotopically Labeled Dietary Phenolics; D. Barron, C. Smarrito-Menozzi, R. Fumeaux, and F. Viton Interactions of Flavan-3-ols Within Cellular Signaling Pathways; C. G. Fraga and P. I. Oteiza Flavonoids and Vascular Function; A. Rodriguez-Mateos and J. P. E. Spencer Effects of Flavonoids on the Vascular Endothelium: What Is Known and What Is Next? A. R. Weseler and A. Bast Green Tea Flavan-3-ols and Their Role in Protecting Against Alzheimer,s and Parkinson,s Disease Pathophysiology; O. Weinreb, T. Amit, M. B. H. Youdim, and S. Mandel Flavonoids and Neuroinflammation; D. Vauzour and K. Vafeiadou Effects of Flavonoids on Cognitive Performance; S. M. Poulose and B. Shukitt-Hale Flavonoids and Oral Cancer; T. Walle Flavonoids and Cancer-Effects on DNA Damage; P. Sitthiphong, A. Klinder, J. W. Lampe, and I. Rowland Index