Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories.
Preface1. The Role of the Genetic Code in the DNA Methylation Landscape Formation2. DNA Methylation Microarrays3. Ultra Deep Sequencing of Bisulfite Modified DNA4. Bioinformatics Tools in Epigenomic Studies5. Genome-Wide DNA Methylation Changes During Aging6. The Dynamics of Histone Modifications During Aging7. The DNA Methylomes of Cancer8. Non-coding RNA Regulation of Health and Disease9. Genome-Wide Epigenetic Studies in Neurological Diseases10. Epigenetic Deregulation in Autoimmune Disease11. Genome-Wide DNA and Histone Modification Studies in Metabolic Disease12. Epigenomic Studies in Epidemiology13. Clinical Applications of Epigenomics