Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.
Preface Gary Felsenfeld 1. Introduction and History Suming Huang 2. Histone Modifications Michael Litt 3. Genomic imprinting in mammals - memories of generations past Nora Engel 4. Polycomb and trithorax factors in transcriptional and epigenetic regulation Priscilla Nga Ieng Lau and Chi Wai Eric So 5. Chromatin dynamics and genome organization in development and disease Changwang Deng, Bhavita Patel, Yangqiu Li and Suming Huang 6. ncRNA function in chromatin organization Keith E. Giles, Jessica L. Woolnough and Blake Atwood 7. Epigenetic Gene Regulation and Stem Cell Function Aissa Benyoucef and Marjorie Brand 8. Epigenetic Inheritance Benjamin B. Mills, Christine M. McBride and Nicole C. Riddle 9. Transgenerational epigenetic regulation by environmental factors in human diseases Yuanyuan Li 10. Identification of intergenic long non-coding RNA by deep sequencing Gangqing Hu and Keji Zhao 11. Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA Alex Xiucheng Fan, Mir A. Hossain, Jared Stees, Ekaterina Gavrilova and Jorg Bungert 12. Genetically altered cancer epigenome Ming Tang, Huacheng Luo and Jianrong Lu 13. Long non-coding RNAs and carcinogenesis Felix Recillas-Targa 14. Epigenetics of physiological and premature aging Shrestha Ghosh and Zhongjun Zhou 15. Epigenetic Effects of Environment and Diet Jason O. Brant and Thomas P. Yang 16. Epigenetic control of stress-induced apoptosis Lei Zhou 17. Structure, Regulation, and Function of TET Family Proteins Xin Hu, Yun Chen and Zhizhuang Joe Zhao 18. Epigenetic drugs for cancer therapy Bowen Yan, Xuehui Li, Yurong Yang, Wei Jian and Yi Qiu 19. Epigenetic Mechanisms as Key Regulators in Disease. Clinical Implications and Case Studies Abdelhalim Boukaba, Fabian Sanchis-Gomar, Jose Luis Garcia-Gimenez