Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience.
Preface Foreword by Annette Kirshner Section I: Neurodevelopmental Disorders 1. Overview of the Role of Environmental Factors in Neurodevelopmental Disorders 2. Genetic Factors in Environmentally-Induced Disease 3. Fetal Alcohol Spectrum Disorders 4. Prenatal Infection 5. Attention Deficit-Hyperactivity Disorders 6. Organic Mercury Compounds 7. Lead 8. Endocrine Disruptors 9. Summary and Perspectives 10. Overview of Environmental Factors in Neurodegenerative Disorder Part II: Neurodegenerative Disorders 11. Western Pacific ALS-PDC: a Prototypical Long-Latency Environment Neurodegenerative Disorder 12. Parkinson's Disease Epidemiology 13. Parkinson's Disease: Mechanisms and Biological Plausibility 14. Genetics of Parkinson's Disease 15. Environmental Risk Factors in Alzheimer Disease 16. Amyotrophic Lateral Sclerosis: Environmental Factors 17. Gene-Environment Interactions in Huntington's Disease 18. Infection, Neuroinflammation and Neurodegenerative Diseases 19. Late Effects of Early Exposures 20. Summary and Perspectives