Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines. This book supplies an in-depth discussion of drug-induced hepatoxicology, covering mechanisms, histopathology, management, risk factors, and patterns of drug and toxin-induced disease. It includes contributions international experts.
MECHANISMS OF LIVER INJURY. Drug-Induced Liver Disorders. P450-Activation of Toxins and Hepatotoxicity. Oxidative Stress, Antioxidant Defense and Liver Injury. Hepatotoxicity Due to Mitochondrial Injury. Mechanisms of Cell Death And Relevance to DrugHepatotoxicity.Role of Membrane Transport in Hepatotoxicity and Pathogenesis of Drug-Induced Cholestasis.Immunological Mechanisms in Drug-Induced Liver Injury. Mechanistic Role of Acyl Glucuronides. Nonparenchymal Cells, Inflammatory Macrophages and Hepatotoxicity.Role of Tissue Repair in Liver Injury. Pharmacogenomics and Toxicogenomics. DIAGNOSIS AND MANAGEMENT. Clinico-Pathological Patterns of Drug and Toxin-Induced Liver Disease.Histopathology of Drug-Induced Liver Disease. Risk Factors for Drug-Induced Liver Disease.Causality Assessment. Management of Drug-Induced Liver Disease. HEPATOTOXICITY OF SPECIFIC DRUGS. Mechanisms of Acetaminophen-Induced Liver Disease. Acetaminophen-Pathology and Clinical Presentation of Hepatotoxicity. Mechanisms Underlying theHepatotoxicity of Non-Steroidal Anti-Inflammatory Drugs. Non-Steroidal Anti-Inflammatory Drugs- Pathology and Clinical Presentation of Hepatotoxicity. Mechanisms, Pathology and Clinical Presentation of Hepatotoxicity of Anesthetic Agents. AnticonvulsantAgents.Psychotropic Drugs and Drugs of Abuse. Antimicrobials and Antifungal Agents.Antituberculosis Agents. Antiviral Agents. Hepatotoxicity of Cardiovascular and Antidiabetic Drugs. Cancer Chemotherapy. Immunomodulating Agents and the Transplant Situation.Methotrexate Controversies. Hormones and Hormone Antagonists. Mushroom Poisoning: A Clinical Model of Toxin-Induced Centrilobular Necrosis. Alternative Medicine, Vitamins and Natural Hepatotoxins. Occupational and Environmental Hepatotoxicity. REGULATORYPERSPECTIVES. Regulatory Perspectives. Index.