First isolated as a chemical compound by a Russian chemist in 1866, dimethyl sulfoxide (DMSO) proved to be a near-perfect solvent for decades before its remarkable biological and medical activities were discovered. DMSO is one of the most prodigious agents ever to come out of the world of drug development. Its wide range of biological actions involving plants, animals, and humans has led to the publication of tens of thousands of articles in the scientific literature. Dimethyl Sulfoxide (DMSO) in Trauma and Disease examines the major clinical uses of DMSO in humans as supported by basic evidence derived from experiments in animals, including its effects in disorders such as osteoarthritis, interstitial cystitis, gastrointestinal inflammatory changes, scleroderma, respiratory distress, myasthenia gravis, cardiac disease, traumatic brain injury, and Alzheimer's disease. The effects of DMSO on pain, cancer, stroke, and spinal cord injury are also discussed. The book explores how its chemical structure is able to react and deactivate toxic molecules generated by DNA damage, free radical formation, inflammation, oxidation, and infection.
For the first time, the collective data on the biological, chemical, and medical actions of DMSO are presented and analyzed from the published scientific literature. Clearly written, the book incorporates easy-to-understand scientific descriptions that appeal both to health care professionals and the millions of people worldwide who have used DMSO for an assortment of ailments as a prescriptive or off-label medication.
Chemistry of DMSO Chemical Structure and Properties of DMSO DMSO Solvation and Chemical Activity Protein Folding Permeability Enhancement DMSO as a Chemical Chaperone DMSO as an Electrolyte Cryoprotection DMSO in the Sea and the Atmosphere References DMSO in Basic Pharmacology Absorption, Fate, and Excretion of DMSO Penetration Chemical Chaperones DMSO as a Pain Medication Anti-Inflammatory Prostaglandins Cardiac Disease Ulcerative Colitis Skin Penetrant Wound Healing Burns and Scar Tissue Respiratory Stimulation Acute Respiratory Distress Syndrome Experimental Blunt Chest Trauma Autophagy Diuresis Cholinesterase Inhibition Solvent Action Veterinary Uses Teratology and LD Ocular Effects Intrawound Administration of DMSO References DMSO Clinical Pharmacology DMSO in Disease Pain Interstitial Cystitis Gastrointestinal Disorders Autoimmune Disorders Respiration Amyloidosis and Scleroderma Thromboembolic Events Platelet Deaggregation and Free Radical Scavenging Tissue Factor and Inflammation Clinical Toxicology References DMSO in Genetics Protection from Ionizing Radiation DMSO Protection of Single- and Double-Stranded DNA Breaks DMSO in Cellular Differentiation Cancer Stem Cells and Differentiation References DMSO in Basic Microbiology DMSO in Bacterial Infections DMSO and Pathogens DMSO in Viral and Fungal Pathology References DMSO in Clinical Microbiology How Bacteria Achieve Antibiotic Resistance DMSO in Multidrug-Resistant Tuberculosis References DMSO in Malignancy DMSO and Neoplasia Friend Leukemia Cells HL-60 Human Cell Line Metastatic Liver Disease DMSO Combined with Anticancer Agents DMSO in Extravasation Cancer and Radiation Onyx Embolization References DMSO in Basic Neuroprotection Brain Trauma Overview Secondary Injury and Ischemic Penumbral Neurons DMSO in Experimental Brain Trauma Free Radicals in Brain Injury Cerebral Hemodynamic Function in Brain Injury Prostaglandins Tissue Factor Cerebral Blood Flow Concussions DMSO in Brain Concussion DMSO Combined with a Glycolytic Intermediate DMSO in Experimental Brain Ischemia Ethical Considerations for Using Nonhuman Primates in CNS Injuries Role of DMSO in Experimental Stroke DMSO in Missile Injury to the Brain DMSO Compared to Mannitol in Missile Injury DMSO in Aging Research DMSO in Experimental Dementia DMSO in Experimental Spinal Cord Injury DMSO as a Solvent References DMSO in Clinical Neuroprotection Overview of Clinical Traumatic Brain Injury Head Injury in Children Cost and Consequences of Traumatic Brain Injury Chronic Traumatic Encephalopathy Treating Traumatic Brain Injury DMSO in Traumatic Brain Injury Optimal DMSO Dose for Traumatic Brain Injury Comparing DMSO Doses, Duration of Treatment, and Use as a First- or Second-Line Treatment for Traumatic Brain Injury DMSO in Intracranial Aneurysm Hemorrhage DMSO Compared to Progesterone for Traumatic Brain Injury DMSO + Fructose-1,6-Disphosphate (FDP) for Ischemic Stroke References