This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells. Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer's Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.
.- 1 Tooth development and dental tissue derived stem cells: Isolation, characterization, storage and problems .- 2 Immunosuppressive properties of dental stem cells .- 3 miRNA regulation in dental stem cells: From development to terminal differentiation .- 4 Signaling pathways in dental stem cell during their maintenance and differentiation .- 5 Dental stem cells peculiarities and their importance for regenerative medicine .- 6 Dental stem cells in oral maxillofacial and craniofacial regeneration .- 7 Dental stem cells: Possibility for generation of a bio-tooth .- 8 Dental stem cells for bone tissue engineering .- 9 Genetically engineered dental stem cells for regenerative medicine .- 10 Dental stem cells: Their potential in neurogenesis and angiogenesis .- 11 Dental stem cells derived IPS cells: A new tool for cellular therapy .- 12 Future perspectives of dental stem cell engineering and ethical considerations.