Written for basic scientists, students, and educators, this first-of-its-kind reference covers immunity, immunopathology, and direct intercellular communication through gap channels. It examines cell biology, inflammation, and inflammatory diseases, including those affecting the lung, the brain, and the skin. It also discusses athrosclerosis and connexin-based therapeutic approaches in inflammatory diseases. The contributors explore basic research, clinical practice, and commercial applications and examine the importance of cellular interactions, especially connectivity in the component cells of the immune system. This reference also describes connexin-specific pharmacology and therapeutic approaches under development for future use.
IMMUNOLOGY AND CELL BIOLOGY Gap junction intercellular communication in the immune system; Oviedo-Orta and Evans Structural analysis and characterization of gap junction channels and connexins in the immune system; Krenacs Methodological approaches to study intercellular communication through gap junction channels in the immune system; Taffet Connexins in dendritic cells; Saez Role of gap junctions and connexins in antigen presentation and T-cell activation; Neefjes Gap junctions and connexins in immune defense against tumors; Salazar INFLAMMATION AND INFLAMMATORY DISEASES Hypoxia and endothelial cell dysfunction; Kidder and Tyml Lung inflammation; Chanson and Koval Brain inflammation - Role of microglia; Giaume Atherosclerosis; Kwak Skin inflammation; Martin CONNEXIN-BASED THERAPEUTICAL APPROACHES IN INFLAMMATORY DISEASES