This contemporary book covers significant new knowledge that has emerged during the last two decades and, thus, provides novel antibody phylogenetic perspectives relevant to development of new antibody-based therapeutics and vaccines. It fills a much-needed niche in the area of immunoglobulin genetics across species from a comparative perspective. New insights and perspectives from immunoglobulin genetics from species such as sea lamprey, cattle, marsupial, bat, rat, rabbit, and swine-other species than the traditional subjects of mice and humans-are relevant to antibody design and engineering. These new perspectives find direct application in the cutting-edge areas of antibody design, engineering and therapeutics, antibody-drug conjugates, and novel antibody-based vaccines. This book fills the need to provide updated knowledge of this newly exploded area that is finding applications in new drug development. No other competing books on the topic are available in the market.
The book will be of great interest to immunologists, immunology researchers, immunogeneticists, researchers in pharmaceutical science, those involved in the infectious disease and antibody therapeutics areas, and many others.
Variable Lymphocyte Receptor-Based Adaptive Immunity in the Agnathan Sea Lamprey; Marion J. Parsons, Justin T. H. Chan, Heng Sun, and Gotz R. A. Ehrhardt Immunoglobulin Genes in Tetrapods; Yi Sun and Yaofeng Zhao The Immunoglobulin Genes of Bats; J. E. Butler, Nancy Wertz, and Michelle L. Baker Marsupial and Monotreme Immunoglobulin Genetics; Robert D. Miller and Victoria L. Hansen Organization of the he Immunoglobulin Heavy- and Light-Chain Loci in the Rat; Peter M. Dammers, Jacobus Hendricks, Peter Terpstra, Nicolaas A. Bos, and Frans G. M. Kroese Generation of the Antibody Repertoire in Rabbits: Role of Gut-Associated Lymphoid Tissues; Kari M. Severson and Katherine L. Knight The Immunoglobulin Genes of Domestic Swine; J. E. Butler and Nancy Wertz Bovine Immunoglobulin Genetics: A Phylogenetic Perspective; Yfke Pasman and Azad K. Kaushik Informatic Tools for Immunoglobulin Gene Sequence Analysis; Lena Hazanov, Miri Michaeli, Gitit Lavy-Shahaf, and Ramit Mehr Index