Multiple sclerosis is the most common cause of neurological disability in young and middle-aged adults. This fully updated and revised new edition provides a detailed account of the many neuropsychiatric disorders associated with MS and is relevant to both the research and the clinical setting. Using the latest brain imaging findings and results from treatment trials, the symptoms, assessment, diagnosis, and treatment of depression in MS are covered, as are psychosocial factors and the link between depression and MRI abnormalities. Subsequent chapters focus on cognitive dysfunction in MS, including the natural history of cognitive change, the use of screening instruments and neuropsychological batteries, brain imaging correlations and management strategies. The book concludes with a survey of the behavioral benefits and risks associated with disease-modifying drugs. It will be valuable to all mental health professionals, neurologists, and others caring for those affected by MS.
Foreword G. Comi; 1. Multiple sclerosis: diagnosis and definitions; 2. Depression: prevalence, symptoms, diagnosis and clinical correlates; 3. Depression: aetiology and treatment; 4. Multiple sclerosis, bipolar affective disorder and euphoria; 5. Multiple sclerosis and pseudobulbar affect; 6. Multiple sclerosis and psychosis; 7. Cognitive impairment in multiple sclerosis; 8. The natural history of cognitive change in multiple sclerosis; 9. Cognitive impairment in multiple sclerosis: detection, management and significance; 10. Neuroimaging correlates of cognitive dysfunction; 11. Multiple sclerosis, disease modifying treatment and behavioral change; 12. Multiple sclerosis: a subcortical, white matter dementia?