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Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds
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Main description:

Natural products play crucial roles in modern drug development, and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug discovery programs. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds presents cutting-edge research in the chemistry of bioactive natural products and demonstrates how natural product research continues to make significant contributions in the discovery and development of new medicinal entities. In 21 chapters, this book highlights chemistry and pharmaceutical potential of natural products in modern drug discovery processes, and covers the synthesis and semi-synthesis of potentially bioactive natural products. Written for phytochemists, synthetic chemists, combinatorial chemists, as well as other practitioners and students in related fields, the book features chemical advances in naturally occurring organic compounds and describes their chemical transformations and structure-activity relationships.


Contents:

Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds. Impact of Solid-Supported Cyclization-Elimination Strategies toward the Development of Natural Product Inspired Molecules in Drug Discovery Research. Synthesis and Biological Studies of Novel beta-Lactams. Applications of Isatin Chemistry in Organic Synthesis and Medicinal Chemistry. Role of Organic Carbamates in Anticancer Drug Design. Rational Design of New Molecules of Biological Significance from Phenolic Constituents of Some Tropical Plants as Renewable Materials. Synthesis and Biological Activity of Promising Azole Marine Products: Largazole and Neopeltolide. Omega-3 (Ie-3) Polyunsaturated Fatty Acids. Structure and Biological Activity of Natural Melanin Pigments. Recent Acquisitions on Naturally Occurring Oxyprenylated Secondary Plant Metabolites. Role of Curcumin in Ameliorating Neuroinflammation and Neurodegeneration Associated with Alzheimer's Disease. Plant Metabolites. X-Ray Structural Behavior of Some Significant Bioactive Steroids and Their Chemistry in the Crystal Packing and Related Matters. Three-Dimensional Structure of Xanthones. Gambogic Acid. Neuroplasticity as a New Approach to the Pathophysiology of Depression and the Role of Antidepressants in Inhibiting Brain Stress-Induced Changes. Statins. Molecular Aspects of Fungal Bioactive Polyketides. Marine Microalgal Metabolites. Rosmarinic Acid. Enhancement of Natural Antioxidants in Plants by Biosynthetic Pathway Modulation. Plant as Biofactories of Pharmaceuticals and Nutraceuticals.


PRODUCT DETAILS

ISBN-13: 9781439891681
Publisher: Taylor & Francis (CRC Press Inc)
Publication date: March, 2013
Pages: 590
Dimensions: 178.00 x 254.00 x 30.00

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