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Checkpoint Responses in Cancer Therapy
by Wei Dai
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Main description:

Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.


Feature:

First book to summarize recent advances in identifying components of cell-cycle checkpoints and validating the use of checkpoint proteins as targets for the development of anticancer drugs


Distinguished authors write on topics that range from the molecular players affecting DNA synthesis and the response to DNA damage, to advances in the identification of inhibitors for individual mitotic kinases


Offers a summary of their findings for researchers in the pharmaceutical and biotechnology industries


Valuable resource for cancer researchers studying of cell-cycle regulation, signal transduction, and apoptosis


Back cover:

Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called "checkpoints" – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.


Contents:

Preface Action of the RB pathway in response to therapeutic agents Erik S. Knudsen Targeting the p53/MDM2 pathway for cancer therapy Lyubomir T. Vassilev DNA topoisomerases as targets for the chemotherapeutic treatment of cancer Neil Osheroff Targeting the DNA damage checkpoint (ATM/ATR) Wafik S. El-Deiry (Not in yet) Compounds that abrogate the G2 checkpoint Takumi Kawabe CDK inhibitors as anti-cancer agents J. de Bono CHFR as a potential anti-cancer target T. Tokino Antimicrotubule agents M. Villalona-Calero Kinesin motor inhibitors as effective anti-cancer drugs A. Giannis Targeting the spindle checkpoint in cancer chemotherapy Hongtao Yu Anti-proliferation inhibitors targeting aurora kinases Daruka Mahadevan Plks as novel targets for cancer drug design Wei Dai Do histone deacetylase inhibitors target cell cycle checkpoints that monitor heterochromatin structure? Brian G. Gabrielli


PRODUCT DETAILS

ISBN-13: 9781597452748
Publisher: Springer (Humana Press)
Publication date: June, 2008
Pages: 328

Subcategories: Oncology