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This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals.
This new edition of the classic book for groups working in experimental and clinical hepatology continues its traditional strength of relating molecular physiology to understanding disease pathology and treatment. The editors are eminent scientists in the area of hepatology and each has an outstanding record.
Proceedings of the Third Baveno International Consensus Workshop on Definitions, Methodology and Therapeutic Strategies. The participants attempted to develop consensus definitions of key events in portal hypertension and variceal bleeding, diagnostic and therapeutic issues, and the complications of therapies for portal hypertension, as well as producing updated guidelines. The lectures summarized the consensus reached in the earlier workshops, addressed two important new areas of research, and analyzed the quality of trials in portal hypertension and other fields of hepatology.
Diseases of the Liver and Biliary System continues to be the pre-eminent textbook of choice for trainee as well as practising gastroenterologists who want a clear and lucid description of the very latest issues in this growing discipline. Every chapter has been updated with the most recent advances in the study and control of hepatitis, in its various forms. Technical and therapeutic advances have appeared in all areas of hepatology, in particular portal hypertension, liver tumours, genetic diseases and imaging, both diagnostic and therapeutic. All are brought up-to-date in the very readable style characteristic of this standard text.
Hepatitis C infects 170 million people worldwide, and has been labelled the 'silent epidemic' as a result of its concealed attack on the liver. This multidisciplinary overview covers basic concepts related to the discovery of the virus, development of serological and nucleic acid tests to detect infection, the structure of the virus genome, generation of virus gene products, and proposed replication scheme. It then goes on to introduce the epidemiology, transmission, pathogenesis of infection, the development of hepatocellular carcinoma associated with chronic virus infection, and current strategies for treatment. The book then discusses advances in cell culture systems, animal models of infection, and emerging treatments and vaccine development. Through its coverage of basic science, clinical consequences, and methods of research, this integrated and accessible account will be of immense value to biomedical scientists and clinicians alike, and a useful introduction for all those studying the virus and its effects.