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Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.- Provides current status and future developments in CE analysis of pharmaceuticals.- Explains how to develop and validate methods.- Includes major pharmaceutical applications including assays and impurity testing.
This handbook provides a wide overview of the field, fundamental understanding of the synthetic methods and structure/property correlation, as well as studies related to applications in a wide range of subjects. The handbook also provides 1H and 13C NMR spectra, FTIR spectra, DSC and TGA thermograms to aid in research activities. Additional tables on key NMR and FTIR frequencies unique to benzoxazine, heat of polymerization, Tg, and char yield will greatly aid in the choice of proper benzoxazine for a specific application.Provides thorough coverage of the chemistry and applications of benzoxazine resins with an evidence-based approach to enable chemists, engineers and material scientists to evaluate effectivenessFeatures spectra, which allow researchers to compare results, avoid repetition and save time as well as tables on key NMR frequency, IR frequency, heat of polymerization, of many benzoxazine resins to aid them in selection of materialsWritten by the foremost experts in the field
Today, more and more people are beginning to rediscover the healing powers of roots and plants. Indeed, some of the most frequently prescribed and powerful drugs are based on plant extracts.Jan de Vries has researched as far back as the twelfth century and has recorded the folk wisdom of various countries, learning from them the popular remedies passed on by their forebears.In Traditional Home and Herbal Remedies, he shares some of these secrets with his readers. Everyone who agrees with his philosophy that nature has a way to help every illness will find this book an invaluable source of information and encouragement.
The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered "e;"e;the Bible"e;"e; by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a "e;"e;first-read"e;"e; or "e;"e;bedside book"e;"e; for readers who are embarking on a career in medicinal chemistry.NEW TO THIS EDITION: * Focus on chemoinformatics and drug discovery * Enhanced pedagogical features* New chapters including: - Drug absorption and transport - Multi-target drugs* Updates on hot new areas: NEW! Drug discovery and the latest techniques NEW! How potential drugs can move through the drug discovery/ development phases more quickly NEW! Chemoinformatics
This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.* Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy.* Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course. * Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study. * Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry.* Expanded coverage of pharmacogenetics* Expanded coverage of drug transporters and their role in interactions* Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions* A new chapter on drug discovery that focuses on oncologic agents* Inclusion of therapeutic antibodies in chapter on biotechnology products
Focuses on various areas in ocular research, from different approaches to dry eye to gene therapy in the management of retinal diseases. This book is suitable for ocular investigators and ophthalmologists as it brings them information on promising therapeutics. It provides insight for drug delivery and for managing diseases, such as macula edema.
Novel Anticancer Agents offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively.Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the fieldPresents drug discovery strategiesDiscusses regulatory issues surrounding drug development