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The Advances in Virus Research series covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.This eclectic volume contains six reviews covering topics relating to plant viruses, evolution of viruses with hosts and cell recognition by viruses.Six Comprehensive Reviews on:* Varicella Virus - Mononuclear Cell Interaction* Evolution of Cell Recognition by Viruses: A Source of Biological Novelty with Medical Implications* Infectious Pancreatic Necrosis Virus: Biology, Pathogenesis and Diagnostic Methods* Structures of Picrona-like plant viruses: Implications and Applications* Cucumoviruses* Co-Evolution of Viruses with Hosts and Vectors and Possible Paleontology

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A valuable, new source, Molecular Medical Parasitology is the only text of its kind -- one that applies broad concepts and current scientific advances from both molecular biology and biochemistry to the study of parasitic organisms. An internationally renowned team of scientists and physicians places parasites in their broad biological contexts while still emphasizing the specifics that differentiate these organisms. Not only will researchers and faculty in parasitology find this an indispensable guide, physicians will benefit from the thorough coverage molecular biology and biochemistry's current influences on treatment and management of parasitic diseases.Features the most up-to-date scientific methods behind the medical management of parasitic diseasesApplies the most current synthesis of molecular biology and biochemistry to parasitic organismsContains many informative figures and clear illustrations

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In May 1993, a cluster of cases of a lethal disease among healthy young people brought the attention of the world to the southwestern deserts. A previously unknown disease was killing up to 80% of the people it infected. The reaction in the area and across the nation mixed fear, lack of information, and the struggles of doctors to save the victims of an unknown killer with hard science and the age old rhythmns of the desert. What came out was the story of a virus that had been killing since man arrived in the American continents, Hantavirus, with deadly relatives across the Americas and across the world. This book explains why and how the virus kills, and why it is still killing today. Why all of the science aimed at a virus identified back in 1993 has not brought a vaccine or a cure is part of the story, as is how that killer virus fits into the story of "e;new"e; diseases across the world. The story of hantavirus disease, what has happened since that first outbreak, and what the real risks are is laid out by an experienced scientist and an award winning journalist living and working in the area of the 1993 outbreak.Covers the full story of the recent hantavirus outbreakIncludes interviews with survivors, and local reactionPresents the science in lay termsPlaces the event in the broader context of emerging diseases worldwideThe only account which takes the reader beyond the initial outbreak in 1993-1994, bringing them up to late 1998Discusses hantavirus disease in the U.S., Argentina, and Canada

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This volume is the first in a planned series of thematic volumes for Advances in Virus Research. It covers the etiology, pathogenetic mechanisms, and clincial consequences of human neurotropic viruses. Buchmeier is a virologist, Campbell an immunologist, and both are extremely well known in their fields.Numerous illustrations including colourKnowledgeable discussion of the potential role of viral infections in teratogenic and developmental disordersFrank discussion of the role of stress in diseaseBehavioural consequences of chronic CNS infection

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Although most strains of E. coli bacteria are harmless and live in the intestines of healthy humans and animals, several strains can produce powerful toxins and cause severe illness in humans. This versatile pathogen is best known for being transmitted to humans through contaminated foods - such as undercooked meat and unpasteurized fruit juice - and has attracts much attention when serious outbreaks occur. E. coli is capable of causing a wide variety of diseases - from urinary tract infections to meningitis. A considerable amount of media coverage has recently been devoted to one particular strain of E. coli, responsible for an estimated 73,000 cases of infection and 61 deaths in the United States each year. Knowing more about the biology, the evolution, and the genetic basis of this pathogen is crucial to future prevention of infection and illness. Pathogenic E. coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. Pathogenic E. coli concludes with a presentation of virulance factors, common to two or more pathotypes. This unique collection presents timely and vital information on understanding the inner workings of E. coli, which will lend key insights into disease prevention research.Single source of information of E. coli pathogenesisExpert authorsComprehensive coverageMolecular mechanismsBiology, evolution and genomicsRecent advances

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This is the first text to examine the connection between virology and human disease. It is also the first book to integrate basic virology with pathophysiological conditions. By contrast, most virology textbooks focus on the molecular biology involved without adequate reference to physiology. Viruses and Human Disease is four-color throughout and contains clearly labeled figures and tables.Key Features*Provides a concise overview of animal viruses, emphasizing those causing diseases in humans;* Integrates discussion of molecular biology, epidemiology, and the history of human viruses;* Presents treatment of prions, gene therapy, and vaccine development;* Illustrated in color by an expert virologist;* Includes world maps depicting the current distribution of existing and newly emerging viruses

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Biomedical Applications of Microprobe Analysis is a combination reference/laboratory manual for the use of microprobe analysis in both clinical diagnostic and research settings. Also called microchemical microscopy, microprobe analysis uses high-energy bombardment of cells and tissue, in combination with high resolution EM or confocal microscopy to provide a profile of the ion, metal, and mineral concentrations present in a sample. This allows insight into the physiology and pathophysiology of a wide variety of cells and tissues.This book describes methods for obtaining detailed information about the identity and composition of particles too small to be seen with the naked eye and describes how this information can be useful in diagnostic and biomedical research.Up-to-date review of electron microprobe analysisDetailed descriptions of sample preparation techniquesRecent technologies including confocal microscopy, infrared microspectroscopy, and laser raman spectroscopyOver 100 illustrations with numerous specific applicationsContributions by world-renowned experts in the fieldBrief summary of highlights precedes each chapter

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Rabies offers a complete account of one of the oldest known diseases threatening public health today. Unlike most research-oriented descriptions of rabies, this book provides a narrative about the disease and its etiologic agent, encompassing the historical background to recent developments. The emphasis on the basic biology and molecular virology of the disease is intended to convey an understanding of the underlying mechanisms involved in the disease - essential information for diagnosis and prevention strategies. Current methods used in defining geographic origins and animal species of rabies viruses in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. The latest approved methods for controlling rabies in wildlife species are also covered. This account of rabies will interest clinicians, public health advisors, epidemiologists, research scientists, and anyone involved in diagnosing, treating, controlling, and preventing this disease.Key Features* A history of rabies from antiquity to the modern era* Basic biology and molecular virology* Epidemiological aspects* Pathogenesis and pathology of the disease* Clinical manifestations and diagnostic evaluation in humans and animals* Preventive measures in humans and animals

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Proteases are enzymes that essentially "e;eat"e; protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search.Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area.Includes information on the basic biology and function of proteasesProvides global survey of current research efforts in protease inhibitorsIllustrates how structure-based drug design targets effective and selective compoundsHighlights important diseases that provide economically important targetsDescribes the role of proteases as important new targets for drug discovery

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