Rhabdoviruses and Filoviruses are single-stranded, non-segmented, negative-strand RNA viruses, many of which cause significant morbidity and mortality in humans and animals. Certain members of these virus families have been used as excellent model systems to understand the molecular biology of replication, host responses to infections, and viral countermeasures. Rhabdoviruses have also been used as vaccine vectors as well as oncolytic agents.Studies on Filoviruses have now provided significant insights into how they enter susceptible cells, replicate and cause disease, and also how they evade the host's immune mechanisms. This book addresses the most recent findings on Rhabdovirus and Filovirus structure, replication mechanisms, host cell responses to virus infections and viral countermeasures. Chapters on emerging viruses as well as approaches for therapeutic interventions have also been included.This book represents an authoritative text that brings together the most recent advances on the cellular and molecular biology of Rhabdo- and Filoviruses, including mechanisms of pathogenesis.
Overview of Rhabdo- and Filoviruses (Asit K Pattnaik & Michael A.Whitt); Rhabdovirus Structure (Ming Luo); The Pathway of VSV Entry into Cells (Shem Johnson & Jean Gruenberg); Rhabdovirus Glycoproteins (Yves Gaudin & Michael A Whitt); VSV RNA Transcription and Replication (Jacques Perrault); Host Cell Functions in Vesicular Stomatitis Virus Replication (Phat X Dinh, Anshuman Das, & Asit K.Pattnaik); Cytopathogenesis of Rhabdoviruses (Douglas S Lyles); Assembly and Budding of Rhabdo- and Filoviruses (Ziying Han & Ronald N Harty); Rhabdoviruses as Vaccine Vectors: From Initial Development to Clinical Trials (John K Rose & David K Clarke); Oncolytic Rhabdoviruses (Nicole E Forbes and John C Bell); Use of Rhabdoviruses to Study Neural Circuitry (Melanie Ginger, Guillaume Bony, Matthias Haberl & Andreas Frick); Evolution of Rhabdo- and Filoviruses (Isabel S Novella, John B Presloid & R Travis Taylor); Emerging Rhabdoviruses (Imke Steffen & Graham Simmons); Rabies Virus Replication and Pathogenesis (Andrew W Hudacek & Matthias J Schnell); Activation and Evasion of Innate Immune Response by Rhabdoviruses (Karl-Klaus Conzelmann); Rabies Virus Vaccines (Ying Huang, Clement W Gnanadurai & Zhen F Fu); Filovirus Structure and Morphogenesis (Timothy F Booth, Daniel Beniac, Melissa Rabb, & Lindsey Lamboo); Epidemiology and Pathogenesis of Filovirus Infections (Logan Banadyga & Hideki Ebihara); Filovirus Entry into Susceptible Cells (Rohit K Jangra, Eva Mittler & Kartik Chandran); Filovirus Transcription & Replication (Kristina Brauburger, Laure R Deflube & Elke Muhlberger); Innate Immune Evasion Mechanisms of Filoviruses (Christopher F Basler, Gaya K Amarasinghe & Daisy W Leung); Vaccines and Antivirals for Filoviruses (Chad E Mire & Thomas W Geisbe);