Addressing a major field of interest for oncologists, cell biologists, and other biomedical researchers, Beyond Apoptosis provides an overview of how different biological mechanisms of cell death, senescence and mitotic catastrophe stop the growth of tumor cells treated with anticancer agents.
Written by internationally renowned contributors, this text includes:
- morphological illustrations, as well as a DVD containing documents and video clips from various time-lapse microscopic studies of cell death and mitotic catastrophe
- the role and limitations of apoptosis as a determinant of the toxicity of anticancer agents
- alternative mechanisms of the antiproliferative actions of anticancer drugs and radiation, such as non-apoptotic cell death, cell senescence, and mitotic catastrophe
- non-apoptotic forms of cell death, such as necrosis, paraptosis, autophagic cell death, and others
- morphological and kinetic differences of the various forms of cell death
Historical Status of Apoptosis. Apoptosis as a Determinant of Tumor Progression and Radiation Damage to Normal Tissues. What Does the Clinical Data Tell Us About the Role of Apoptosis in Sensitivity to Cancer Therapy? Response of Solid Tumors to Cancer Therapy: How Relevant is Apoptosis? Section 2: Non-Apoptotic Cell Death Historical Studies of Various Forms of Programmed Cell Death. Historical Studies of Various Forms of Programmed Cell Death. Mechanistic Taxonomy of Cell Death Programs. Serine Proteases in Apoptotic Programmed Cell Death. Caspase-mediated Programmed Cell Death/Apoptosis. Autophagic Cell Death. The Cellular Decision Between Apoptosis and Autophagic Programmed Cell Death. PARP and AIF-dependant Programmed Cell Death. Paraptosis. Section 3: Tumor Senescence in Cancer Treatment. Cell Senescence and its Effects on Carcinogenesis and Tumor Progression. Tumor-suppressing Activities of Senescent Keratinocytes. Inducing Senescence in Cervical Cancer by Targeting Papillomavirus Oncogenes. Drug-induced Tumor Senescence in Tumor Cells. Regulators of Drug-Induced Senescence in Tumor Cells. Mechanisms of Drug-induced Senescence in a Transgenic Mouse Tumor. Chemotherapy-induced Senescence in Clinical Cancer. Section 4: Mitotic Catastrophe and Choosing the form of Death. Mitotic Catastrophe as a Response to DNA Damage in Interphase. How Microtubule-Targeting Agents Kill Cells. Modes of Cell Death by Anti-cancer Agents: The Crucial Importance of Dose. How Do Cells Die After Irradiation?: Time Lapse Studies with Cells in Culture.